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Pharmacokinetics of Insulin Preparations

 

Time of Action

Preparation

Onset, h

Peak, h

Effective Duration, h

Short-acting, subcutaneous

   Lispro

<0.25

0.51.5

34

   Aspart

<0.25

0.51.5

34

   Glulisine

<0.25

0.51.5

34

   Regular

0.51.0

23

46

Short-acting, inhaled

   Inhaled regular insulin

<0.25

0.51.5

46

Long-acting

   NPH

14

610

1016

   Detemir

14

a

1220

   Glargine

14

a

24

Insulin Combinations

   75/2575% protamine lispro, 25% lispro

<0.25

1.5 hb

Up to 1016

   70/3070% protamine aspart, 30% aspart

<0.25

1.5 hb

Up to 1016

   50/5050% protamine lispro, 50% lispro

<0.25

1.5 hb

Up to 1016

   70/3070% NPH, 30% regular insulin

0.51

Dual

1016

   50/5050% NPH, 50% regular insulin

0.51

Dual

1016

aGlargine has minimal peak activity; detemir has some peak activity at 614 h.

bDual: two peaks; one at 23 h; the second several hours later.

References:

  1. Hirsch IB. Insulin analogues. N Engl J Med. 2005 Jan 13;352(2):174-83. [Medline]

  2. DeWitt DE, Hirsch IB. Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. JAMA. 2003 May 7;289(17):2254-64. [Medline]

Created: Dic 31, 2008
Last Modified: 12/31/2008