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18th Edition (August 5, 2011)
|Diagnostic Criteria for Multiple Myeloma|
|Written by G. Firman MD|
|Sunday, 01 March 2009 18:33|
Presence of an M-componenta in serum and/or urine plus clonal plasma cells in the bone marrow and/or a documented clonal plasmacytoma.
PLUS one or more of the following:b
aIn patients with no detectable M-component, an abnormal serum FLC ratio on the serum FLC assay can substitute and satisfy this criterion. For patients, with no serum or urine M-component and normal serum FLC ratio, the baseline bone marrow must have >10% clonal plasma cells; these patients are referred to as having ‘non-secretory myeloma’. Patients with biopsy-proven amyloidosis and/or systemic light chain deposition disease (LCDD) should be classified as ‘myeloma with documented amyloidosis’ or ‘myeloma with documented LCDD,’ respectively if they have >30% plasma cells and/or myeloma-related bone disease.
bMust be attributable to the underlying plasma cell disorder.
cNote: Hemoglobin of 10 g/dl is 12.5 mmol/l [or 100 g/l].
Myeloma-related organ dysfunction (CRAB criteria)
Created: June 17, 2007
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|Last Updated on Saturday, 28 January 2012 14:13|
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