Revised Banff 2017 Classification of Antibody-Mediated Rejection (ABMR) in Renal Allografts

The Banff classification represented the first attempt to formulate an international, consensus based and structured classification system for the diagnosis and categorization of renal allograft biopsy pathology with a particular focus on the development of the morphological criteria for the diagnosis and classification of rejection. Continue reading

Definition and Classification/Staging System for Acute Kidney Injury (AKI)

In 2004, the ADQI group and representatives from three nephrology societies established the Acute Kidney Injury Network (AKIN). Its intentions are to facilitate international, interdisciplinary and intersocietal collaborations and to ensure progress in the field of AKI, including the development of uniform standards for the definition and classification of AKI. As part of this process, the RIFLE nomenclature and classification was modified to a staging/classification system differentiating between AKI stage I, II and III. In addition, a 48-hour time window for the diagnosis of AKI was introduced to ensure that the process was acute.

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Definition and Characteristics of Bartter’s Syndrome

Bartter’s syndrome is a rare disease that most often presents in the neonatal period or early childhood with polyuria, polydipsia, salt craving, and growth retardation. Blood pressure is normal or low. Metabolic abnormalities include hypokalemia, hypochloremic metabolic alkalosis, decreased urinary concentrating and diluting ability, hypercalciuria with nephrocalcinosis, mild hypomagnesemia, and increased urinary prostaglandin excretion.

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Indications of Dialysis in Renal Failure

Indications of dialysis in acute renal failure (ARF)

  • Severe fluid overload
  • Refractory hypertension
  • Uncontrollable hyperkalemia
  • Nausea, vomiting, poor appetite, gastritis with hemorrhage
  • Lethargy, malaise, somnolence, stupor, coma, delirium, asterixis, tremor, seizures,
  • Pericarditis (risk of hemorrhage or tamponade)
  • bleeding diathesis (epistaxis, gastrointestinal (GI) bleeding and etc.)
  • Severe metabolic acidosis
  • Blood urea nitrogen (BUN) > 70 – 100 mg/dl Continue reading

Risk Factors for Contrast-Induced Nephropathy (CIN)

Contrast-induced nephropathy (CIN) is defined as the impairment of renal function and is measured as either a 25% increase in serum creatinine (SCr) from baseline or 0.5 mg/dL (44 umol/L) increase in absolute value, within 48-72 hours of intravenous contrast administration. Continue reading