Comparative Effectiveness of Statin Therapy

HMG CoA-reductase inhibitors or statins are clearly the most effective class of drugs for lowering LDL cholesterol. Those drugs have been associated with a beneficial impact on cardiovascular morbidity and mortality.

 

Comparative Effectiveness of Statin Therapy 

% LDL Reduction 

25-32%

31-39%

37-45%

48-52%

55-60%

60-63%

 Lovastatin

 20 mg

 40 mg

 80 mg

 

 

 

 Pravastatin

 20 mg

 40 mg

 80 mg

 

 

 

 Simvastatin

 10 mg

 20 mg

 40 mg

 80 mg

 

 

 Fluvastatin

 40 mg

 80 mg

 

 

 

 

 Atorvastatin

 

 10 mg

 20 mg

 40 mg

 80 mg

 

 Rosuvastatin

 

 

   5 mg

 10 mg

 20 mg

 40 mg

 Ezetimibe/Simvastatin

 

 

 10/10

 10/20

 10/40

 10/80

 

  

 

References:

  1. Cholesterol Treatment Trialists’ (CTT) Collaboration, Fulcher J, O’Connell R, Voysey M, Emberson J, Blackwell L, Mihaylova B, Simes J, Collins R, Kirby A, Colhoun H, Braunwald E, La Rosa J, Pedersen TR, Tonkin A, Davis B, Sleight P, Franzosi MG, Baigent C, Keech A. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet. 2015 Apr 11;385(9976):1397-405 [Medline]
  2. Weng TC, Yang YH, Lin SJ, Tai SH. A systematic review and meta-analysis on the therapeutic equivalence of statins. J Clin Pharm Ther. 2010 Apr;35(2):139-51. [Medline]
  3. Nicholls SJ, Brandrup-Wognsen G, Palmer M, Barter PJ. Meta-analysis of comparative efficacy of increasing dose of Atorvastatin versus Rosuvastatin versus Simvastatin on lowering levels of atherogenic lipids (from VOYAGER). Am J Cardiol. 2010 Jan 1;105(1):69-76. [Medline]

 

 

 

Created Oct 31, 2017.