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Awaji Criteria for Amyotrophic Lateral Sclerosis (ALS)

The Awaji recommendations for the use of electrodiagnostic studies in the diagnosis of amyotrophic lateral sclerosis (ALS) were proposed to enable earlier diagnosis of ALS to be achieved to meet an acknowledged need to obviate diagnostic delay. Continue reading “Awaji Criteria for Amyotrophic Lateral Sclerosis (ALS)”

Updated Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)

Tuberous sclerosis complex (TSC) is highly variable in clinical presentation and findings. Disease manifestations continue to develop over the lifetime of an affected individual. Accurate diagnosis is fundamental to implementation of appropriate medical surveillance and treatment. Continue reading “Updated Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)”

The 2017 McDonald Criteria for Diagnosis of Multiple Sclerosis (MS)

The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. Continue reading “The 2017 McDonald Criteria for Diagnosis of Multiple Sclerosis (MS)”

Kurtzke’s Expanded Disability Status Scale (EDSS)

The Expanded Disability Status Scale (EDSS), an accepted method of quantifying disability in Multiple Sclerosis (MS) consists of an eight-function system scale monitoring motor, sensory, cerebellar, brain stem, visual, bowel and bladder, pyramidal and other functions.
Continue reading “Kurtzke’s Expanded Disability Status Scale (EDSS)”

Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)

The diagnostic criteria for tuberous sclerosis complex (TSC) were revised at the Tuberous Sclerosis Complex Consensus Conference, July 1998.

Definite TSC: Two major features or one major feature plus two minor features

Probable TSC: One major feature plus one minor feature

Possible TSC: One major feature or two or more minor features

Continue reading “Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)”

Criteria for the Classification of Systemic Sclerosis (Scleroderma)

1980 Criteria for the Classification of Systemic Sclerosis

The American College of Rheumatology (former American Rheumatism Association – ARA) has defined criteria, that are 97 % sensitive and 98 % specific for systemic sclerosis (SSc) as follows:

Major criterion:

  • Proximal diffuse (truncal) sclerosis (skin tightness, thickening, non-pitting induration)

Continue reading “Criteria for the Classification of Systemic Sclerosis (Scleroderma)”

El Escorial Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis (ALS)

The diagnosis of Amyotrophic Lateral Sclerosis (ALS) requires

A. the presence of:
(A:1) evidence of lower motor neuron (LMN) degeneration by clinical, electrophysiological or neuropathologic examination,
(A:2) evidence of upper motor neuron (UMN) degeneration by clinical examination, and
(A:3) progressive spread of symptoms or signs within a region or to other regions, as determined by history or examination, together with

Continue reading “El Escorial Criteria for the Diagnosis of Amyotrophic Lateral Sclerosis (ALS)”

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