Serum Levels That Differentiate Anemia of Chronic Disease from Iron-Deficiency Anemia

Iron deficiency anemia develops when body stores of iron drop too low to support normal red blood cell (RBC) production. Inadequate dietary iron, impaired iron absorption, bleeding, or loss of body iron in the urine may be the cause.

Variable

Anemia of Chronic Disease

IronDeficiency Anemia

Both Conditions

Iron

Reduced

Reduced

Reduced

Trasnferrin

Reduced to normal

Increased

Reduced

Transferrin saturation

Reduced

Reduced

Reduced

Ferritin

Normal to increased

Reduced

Reduced to normal

Soluble transferrin receptor

Normal

Increased

Normal to increased

Ratio of soluble transferrin receptor to log ferritin

Low (<1)

High (>2)

High (>2)

Cytokine Levels

Increased

Normal

Increased

Patients with both conditions include those with anemia of chronic disease and true iron deficiency.

 

 

Reference:

  1. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005 Mar 10;352(10):1011-23. [Medline]

Created: May 03, 2005