Diagnostic Criteria of Langerhans Cell Histiocytosis (LCH)

The diagnosis of Langerhans Cell Histiocytosis (LCH) is based on histological and immunophenotypic examination of lesional tissue. The main feature is the morphologic identification of the characteristic LCH cells. Additionally, positive staining of the lesional cells with CD1a and/or Langerin (CD207) is required for definitive diagnosis.

Diagnostic Criteria of Langerhans Cell Histiocytosis (LCH)

Definitive: 
Based on clinic-pathological evidence with microscopic examination and at least one of the following immunological staining:

  • Langerin (CD 207) positivity
  • CD1a positivity
  • Presence of Birbeck granules on electronic microscopy

Presumptive (or compatible):
Based only on clinico-radiological evidence, without biopsy, as in case of:

e.g.: Pulmonary lesions on CT scan with typical cysts and nodules in a smoker. (however, biopsy should be considered in order to reach a more definitive diagnosis)

 

 

References:

  1. DiCaprio MR, Roberts TT. Diagnosis and management of langerhans cell histiocytosis. J Am Acad Orthop Surg. 2014 Oct;22(10):643-52. [Medline]
  2. Néel A, Artifoni M, Donadieu J, Lorillon G, Hamidou M, Tazi A. Langerhans cell histiocytosis in adults. Rev Med Interne. 2015 Oct;36(10):658-67. [Medline]
  3. Monsereenusorn C, Rodriguez-Galindo C. Clinical Characteristics and Treatment of Langerhans Cell Histiocytosis. Hematol Oncol Clin North Am. 2015 Oct;29(5):853-73. [Medline]

 

Created Sep 24, 2018.

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