Drug-Food Interactions

Drug-food interactions are a significant problem in clinical practice. Foods may alter the effects of drugs by interfering with pharmacokinetic processes, such as absorption and elimination.

Drug–food interactions

Medications which should be taken on an EMPTY stomach
  • Alendronate
  • Ampicillin
  • Astemizole
  • Bethanechol
  • Bisacodyl
  • Captopril (Take 1 hour before meals)
  • Cefibuten
  • Cilostazol
  • Demeclocycline
  • Dicloxacillin
  • Didanosine
  • Etidronate
  • Felodipine
  • Indinavir
  • Lansoprazole (take before eating)
  • Levothyroxine
  • Loracarbef
  • Loratadine
  • Methotrexate
  • Moexipril
  • Mycophenolate mofetil
  • Omeprazole (take before eating)
  • Oxacillin
  • Penicillamine
  • Perindopril
  • Repaglinide
  • Rifabutin
  • Rifampicin
  • Riluzole
  • Roxithromycin (take at least 15 minutes before or after a meal)
  • Sucralfate
  • Sulfadiazine
  • Sulfamethoxazole – trimethoprim
  • Tetracycline (Do not take with milk or other dairy products)
  • Tolcapone
  • Zafirlukast
  • Zalcitabine
Medications which should be Taken with FOOD
  • Allopurinol (take after meal)
  • Amiodarone
  • Amoxicillin Clavulanate
  • Aspirin
  • Atovaquone
  • Baclofen
  • Bromocriptine
  • Carbamazepine
  • Carvedilol
  • Cefpodoxime
  • Chloroquine
  • Cimetidine
  • Clofazimine
  • Diclofenac
  • Divalproex sodium
  • Doxycycline
  • Felbamate
  • Fenofibrate
  • Fenoprofen
  • Fludrocortisone
  • Glyburide/Glibenclamide (take with breakfast)
  • Griseofulvin
  • Hydrocortisone
  • Hydroxychloroquine
  • Indomethacin
  • Iron preparations (Take between meals; if GI upset occurs take with food)
  • Itraconazole
  • Ketorolac
  • Lithium
  • Mebendazole
  • Methenamine
  • Methylprednisolone
  • Metronidazole
  • Misoprostol
  • Naltrexone
  • Naproxen
  • Nelfinavir
  • Niacin
  • Nitrofurantoin
  • Olsalazine
  • Pentoxifylline
  • Pergolide
  • Perphenazine
  • Piroxicam
  • Potassium salts
  • Prednisone
  • Procainamide
  • Ritonavir
  • Salsalate
  • Saquinavir
  • Sevelamer
  • Spironolactone
  • Sulfasalazine
  • Sulfinpyrazone
  • Sulindac
  • Ticlopidine
  • Tolmetin
  • Trazodone
  • Troglitazone
  • Valproic acid
Drug-GRAPEFRUIT interactions: Drugs which may exhibit increased serum concentrations based on this interaction
  • Alprazolam
  • Amiodarone
  • Amlodipine
  • Astemizole
  • Atorvastatin
  • Benzodiazepines
  • Buspirone
  • Carbamazepine
  • Carvedilol
  • Cerivastatin
  • Cilostazol
  • Clarithromycin
  • Clomipramine
  • Codeine
  • Cyclosporine
  • Dapsone
  • Dextromethorphan
  • Diazepam
  • Digoxin
  • Diltiazem
  • Estrogens
  • Erythromycin
  • Felodipine
  • Fentanyl
  • Finasteride
  • Haloperidol
  • Indinavir
  • Itraconazole
  • Lercanidipine
  • Lidocaine
  • Losartan
  • Lovastatin
  • Midazolam
  • Methadone
  • Methylprednisolone
  • Midazolam
  • Nelfinavir
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Ondansetron
  • Paclitaxel
  • Progesterone
  • Progestins
  • Quinidine
  • Ritonavir
  • Salmeterol
  • Saquinavir
  • Sildenafil
  • Simvastatin
  • Sirolimus
  • Tacrolimus
  • Trazodone
  • Triazolam
  • Verapamil
  • Vincristine
  • Warfarin
  • Zaleplon
  • Zolpidem
Drug-ALCOHOL  interactions: Avoid alcohol or alcohol-containing products
  • Abacavir
  • Griseofulvin
  • Isocarboxazid
  • Ketoconazole
  • Metronidazole
  • Phenytoin
  • Procarbazine
  • Selegiline
  • Warfarin

Note: there may be omissions on this list. Absence of a drug does not necessarily indicate that the drug lacks this potential interaction.

 

 

References:

  1. Yamreudeewong W, Henann NE, Fazio A, Lower DL, Cassidy TG. Drug-food interactions in clinical practice. J Fam Pract. 1995 Apr;40(4):376-84. [Medline]
  2. Crowther NR, Holbrook AM, Kenwright R, Kenwright M. Drug interactions among commonly used medications. Chart simplifies data from critical literature review. Can Fam Physician. 1997 Nov;43:1972-6, 1979-81. [Medline]

Created Oct 10, 2011.

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