Relative Potencies of Systemic Glucocorticoids

Glucocorticosteroids are a product of the adrenal cortex and perform a staggering number of physiological effects essential for life. Their clinical use is largely predicated on their anti-inflammatory and immunosuppressive properties.

Glucocorticoid

Approximate Equivalent dose (mg)

Half-life (Biologic) hours

Short-Acting

Cortisone

25

8-12

Hydrocortisone

20

8-12

Intermediate-Acting

Methylprednisolone

4

18-36

Prednisolone

5

18-36

Prednisone

5

18-36

Triamcinolone

4

18-36

Long-Acting

Betamethasone

0.6 – 0.75

36-54

Dexamethasone

0.75

36-54

 

References:

  1. Zoorob RJ, Cender D. A different look at corticosteroids. Am Fam Physician. 1998 Aug;58(2):443-50. [Medline]

Created: April 5, 2005