A diagnosis of primary Sjögren’s syndrome is often made on the basis of a classic triad of symptoms: dryness of the mouth and eyes, fatigue, and pain. Systemic complications, which are present in 30 to 40% of patients, may provide the first clues to the disease.
The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. Continue reading
The Banff classification represented the first attempt to formulate an international, consensus based and structured classification system for the diagnosis and categorization of renal allograft biopsy pathology with a particular focus on the development of the morphological criteria for the diagnosis and classification of rejection. Continue reading