Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons. Gluten is a protein complex found in wheat, rye, and barley. Celiac disease is characterized by a broad range of clinical presentations, a specific serum autoantibody response, and variable damage to the small intestinal mucosa.
Definite diagnosis of CD
History and clinical presentation compatible with CD
- Serological screening compatible with CD: antigliadin antibody (AGA) antiendomysium antibody (AEA), tissue transglutaminase (tTG) antibody.
- Histological findings compatible with CD: villous atrophy
- Obvious clinical and serological response to a gluten free diet (GFD)
- Subject >2 years old
- Rule out other clinical conditions mimicking CD Continue reading