Modified Marsh Classification of Histologic Findings in Celiac Disease (Oberhuber)

Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons. Gluten is a protein complex found in wheat, rye, and barley. Celiac disease is characterized by a broad range of clinical presentations, a specific serum autoantibody response, and variable damage to the smallintestinal mucosa.

Continue reading

Revised Criteria for the Diagnosis of Celiac Disease (CD) Proposed by the ESPGHAN

Definite diagnosis of CD

History and clinical presentation compatible with CD

  1. Serological screening compatible with CD: antigliadin antibody (AGA) antiendomysium antibody (AEA), tissue transglutaminase (tTG) antibody.
  2. Histological findings compatible with CD: villous atrophy
  3. Obvious clinical and serological response to a gluten free diet (GFD)
  4. Subject >2 years old
  5. Rule out other clinical conditions mimicking CD Continue reading