New Diagnostic Criteria for Common Variable Immune Deficiency (CVID)

Common variable immunodeficiency disorders (CVIDs) are the most frequent symptomatic primary immune deficiency condition in adults. The genetic basis for the condition is not known and no single clinical feature or laboratory test can establish the diagnosis; it has been a diagnosis of exclusion. In areas of uncertainty, diagnostic criteria can provide valuable clinical information. Continue reading

Diagnostic Criteria for Common Variable Immunodeficiency (CVI)

Common variable immunodeficiency (CVID) is a rare immune deficiency characterized by low levels of serum IgG, IgA, and/or IgM, with a loss of Ab production. The diagnosis is most commonly made in adults between the ages of 20 and 40 years, but both children and much older adults can be found to have this immune defect.  Continue reading

Common Diagnostic Criteria for Left and Right Atrial Abnormalities

Left Atrial Abnormality

  • Prolonged P wave duration of >120 msec in lead II
  • Prominent notching of the P wave, usually most obvious in lead II, with an interval between the notches of >40 msec (p mitrale)
  • Ratio between the duration of the P wave in lead II and the duration of the PR segment of >1.6
  • Increased duration and depth of the terminal negative portion of the P wave in lead V1 (the P terminal force) so that the area subtended by it exceeds 0.04 mm-sec (Morris index)
  • Leftward shift of the mean P wave axis to between -30 and +45 degrees Continue reading