Case Definition for Ebola Virus Disease (EVD)

Early recognition is critical for infection control. Healthcare providers should be alert for and evaluate any patients suspected of having EVD.

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Typical Laboratory Abnormalities in Alcoholic Liver Disease (ALD)

Alcoholic liver disease (ALD) encompasses a spectrum of injury, ranging from simple steatosis to frank cirrhosis.

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Modified Marsh Classification of Histologic Findings in Celiac Disease (Oberhuber)

Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons. Gluten is a protein complex found in wheat, rye, and barley. Celiac disease is characterized by a broad range of clinical presentations, a specific serum autoantibody response, and variable damage to the small intestinal mucosa.

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Diagnosis of Paget’s Disease of Bone

Paget’s disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix.

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Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)

Disease activity is assessed using a combination of the clinical history, physical examination, organ specific functional tests, and serologic studies.

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Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease (CJD)

Zerr et al. modifying the current clinical diagnostic criteria for sporadic CJD to include the detection of either hyperintensity in the basal ganglia (both caudate nucleus and putamen) or in at least two cortical regions (from either the temporal, parietal or occipital cerebral cortices). This implies that the detection of the specified high signal abnormalities in FLAIR or DWI MRI will be considered at the same level of diagnostic importance as periodic sharp wave complexes on the EEG or 14-3-3 protein detection in the CSF

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Guidelines for Diagnosis of Moyamoya Disease

Moyamoya disease is a cerebrovascular condition predisposing affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches. Continue reading

Diagnostic Criteria for Wilson’s disease

Diagnostic Criteria for Wilson’s disease

  1. Low serum ceruloplasmin levels < 20 mg/dL (Normal range 20-50 mg/dL).
  2. Kayser – Fleischer rings in eyes.
  3. High liver copper levels > 250 micrograms/g dry weight (Normal range <35 micrograms/g dry weight).
  4. High 24 hr urinary copper levels > 100 micrograms /d or > 1.6 mmol/d (Normal range <50 micrograms/d or < 0.8 mmol/d).
  5. Radioisotope copper studies using 64Cu, 67Cu or 65Cu, which assesses ability to incorporate copper into ceruloplasmin. Continue reading

Diagnostic Criteria for Tuberculosis Disease

Definite diagnosis

  • Clinical picture consistent with tuberculosis; bacteriologic confirmation (culture, gene probe/NAA + AFB smear); histologic findings

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Diagnostic Criteria for Thromboangiitis Obliterans (Buerger’s Disease)

Since specificity of Buerger’s disease is characterized by peripheral ischemia of an inflammatory nature and with a self-limiting course, diagnostic criteria should be discussed from clinical of view.

Several different criteria have been proposed for the diagnosis of thromboangiitis obliterans:

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