Modified Marsh Classification of Histologic Findings in Celiac Disease (Oberhuber)

Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons. Gluten is a protein complex found in wheat, rye, and barley. Celiac disease is characterized by a broad range of clinical presentations, a specific serum autoantibody response, and variable damage to the small intestinal mucosa.
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Signs and Symptoms of Acute Radiation Sickness

Acute radiation sickness can be categorized into three phases: prodrome, latency, and illness. The Table, summarizes the constellation of hematologic, gastrointestinal, and neurologic symptoms, along with the time to onset and dose dependence, associated with each of these phases.
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Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease (sCJD)

Classic Creutzfeldt-Jakob Disease (CJD) is a human prion disease. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. This disease is rapidly progressive and always fatal. Infection with this disease leads to death usually within 1 year of onset of illness. The criteria for clinical diagnosis plus the CSF real-time quaking-induced conversion (RT-QuIC) accurately identifies patients with sCJD (sensitivity 97%, specificity 99%).
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Diagnostic Criteria for Wilson’s disease

Diagnostic Criteria for Wilson’s disease

  1. Low serum ceruloplasmin levels < 20 mg/dL (Normal range 20-50 mg/dL).
  2. Kayser – Fleischer rings in eyes.
  3. High liver copper levels > 250 micrograms/g dry weight (Normal range <35 micrograms/g dry weight).
  4. High 24 hr urinary copper levels > 100 micrograms /d or > 1.6 mmol/d (Normal range <50 micrograms/d or < 0.8 mmol/d).
  5. Radioisotope copper studies using 64Cu, 67Cu or 65Cu, which assesses ability to incorporate copper into ceruloplasmin. Continue reading