The Edinburgh Claudication Questionnaire has been shown to be 91 percent specific and 99 percent sensitive for diagnosing intermittent claudication in symptomatic patients.
Continue reading “Edinburgh Claudication Questionnaire”
The Edinburgh Claudication Questionnaire has been shown to be 91 percent specific and 99 percent sensitive for diagnosing intermittent claudication in symptomatic patients.
Continue reading “Edinburgh Claudication Questionnaire”
Grading and staging refers to a semiquantitative assessment of the necroinflammatory activity (grade) and degree of fibrosis (stage) in relation to chronic hepatitis.
Continue reading “Histologic Scoring Systems for Chronic Liver Disease”
Early recognition is critical for infection control. Healthcare providers should be alert for and evaluate any patients suspected of having EVD.
Continue reading “Case Definition for Ebola Virus Disease (EVD)”
Alcoholic liver disease (ALD) encompasses a spectrum of injury, ranging from simple steatosis to frank cirrhosis.
Continue reading “Typical Laboratory Abnormalities in Alcoholic Liver Disease (ALD)”
Celiac disease is a systemic immune-mediated disorder triggered by dietary gluten in genetically susceptible persons. Gluten is a protein complex found in wheat, rye, and barley. Celiac disease is characterized by a broad range of clinical presentations, a specific serum autoantibody response, and variable damage to the small intestinal mucosa.
Continue reading “Modified Marsh Classification of Histologic Findings in Celiac Disease (Oberhuber)”
Paget’s disease of bone (also known as osteitis deformans) is a nonmalignant disease involving accelerated bone resorption followed by deposition of dense, chaotic, and ineffectively mineralized bone matrix.
Continue reading “Diagnosis of Paget’s Disease of Bone”
Acute radiation sickness can be categorized into three phases: prodrome, latency, and illness. The Table, summarizes the constellation of hematologic, gastrointestinal, and neurologic symptoms, along with the time to onset and dose dependence, associated with each of these phases.
Continue reading “Signs and Symptoms of Acute Radiation Sickness”
Classic Creutzfeldt-Jakob Disease (CJD) is a human prion disease. It is a neurodegenerative disorder with characteristic clinical and diagnostic features. This disease is rapidly progressive and always fatal. Infection with this disease leads to death, usually within 1 year of onset of illness. The criteria for clinical diagnosis plus the CSF real-time quaking-induced conversion (RT-QuIC) accurately identifies patients with sCJD (sensitivity 97%, specificity 99%).
Continue reading “Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease (sCJD)”
Moyamoya disease is a cerebrovascular condition predisposing affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches. Continue reading “Guidelines for Diagnosis of Moyamoya Disease”
Wilson’s disease is clinically characterised by hepatic and neurological manifestations related to the accumulation of copper in the liver and the lenticular nuclei, and by Kayser-Fleischer rings. Continue reading “Diagnostic Criteria for Wilson’s disease”
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