Disseminated intravascular coagulation is a clinicopathological diagnosis of a disorder that is defined by the International Society on Thrombosis and Hemostasis (ISTH) as “an acquired syndrome characterized by the intravascular activation of coagulation with loss of localization arising from different causes”. This condition typically originates in the microvasculature and can cause damage of such severity that it leads to organ dysfunction. It can be identified on the basis of a scoring system developed by the ISTH.
Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)
1. Sepsis/severe infection (any microorganism)
2. Trauma (e.g., polytrauma, neurotrauma, fat embolism)
3. Organ destruction (e.g., severe pancreatitis)
Disseminated intravascular coagulation is a condition in which small blood clots develop throughout the bloodstream, blocking small blood vessels. The increased clotting depletes the platelets and clotting factors needed to control bleeding, causing excessive bleeding.