The 2017 McDonald Criteria for Diagnosis of Multiple Sclerosis (MS)

The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. Continue reading

Revised IMWG Diagnostic Criteria for Multiple Myeloma

The International Myeloma Working Group (IMWG) consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable CRAB features (hypercalcaemia, renal failure, anaemia, and bone lesions). Continue reading

Kurtzke’s Expanded Disability Status Scale (EDSS)

The Expanded Disability Status Scale (EDSS), an accepted method of quantifying disability in Multiple Sclerosis (MS) consists of an eight-function system scale monitoring motor, sensory, cerebellar, brain stem, visual, bowel and bladder, pyramidal and other functions.

Continue reading

McDonald Diagnostic Criteria for Multiple Sclerosis (MS)

What Is An Attack?

  • Neurological disturbance of kind seen in MS
  • Subjective report or objective observation
  • 24 hours duration, minimum
  • Excludes pseudoattacks, single paroxysmal episodes Continue reading

Diagnostic Criteria for Multiple Myeloma

Presence of an M-componenta in serum and/or urine plus clonal plasma cells in the bone marrow and/or a documented clonal plasmacytoma.

Continue reading

Knaus Criteria for Multiple System Organ Failure (MSOF)

Multiple systems organ failure is said present when more than one of the system dysfunctions detected by test values exceeding the threshold values.

Continue reading