Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease (CJD)

Zerr et al. modifying the current clinical diagnostic criteria for sporadic CJD to include the detection of either hyperintensity in the basal ganglia (both caudate nucleus and putamen) or in at least two cortical regions (from either the temporal, parietal or occipital cerebral cortices). This implies that the detection of the specified high signal abnormalities in FLAIR or DWI MRI will be considered at the same level of diagnostic importance as periodic sharp wave complexes on the EEG or 14-3-3 protein detection in the CSF
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