Wilson and Jungner Criteria for Screening

In 1968, Wilson and Jungner published 10 “principles” for evaluating screening programs, criteria widely used since then.

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Criteria for Diagnostic of Fat Embolism Syndrome (FES)

Fat embolism syndrome, a condition characterized by hypoxia, bilateral pulmonary infiltrates, and mental status change.

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Diagnostic Criteria for Wilson’s disease

Diagnostic Criteria for Wilson’s disease

  1. Low serum ceruloplasmin levels < 20 mg/dL (Normal range 20-50 mg/dL).
  2. Kayser – Fleischer rings in eyes.
  3. High liver copper levels > 250 micrograms/g dry weight (Normal range <35 micrograms/g dry weight).
  4. High 24 hr urinary copper levels > 100 micrograms /d or > 1.6 mmol/d (Normal range <50 micrograms/d or < 0.8 mmol/d).
  5. Radioisotope copper studies using 64Cu, 67Cu or 65Cu, which assesses ability to incorporate copper into ceruloplasmin. Continue reading