{"id":2426,"date":"2011-07-04T13:27:41","date_gmt":"2011-07-04T13:27:41","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/gasgd\/"},"modified":"2025-05-13T20:28:56","modified_gmt":"2025-05-13T20:28:56","slug":"gasgd","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/es\/gasgd\/","title":{"rendered":"Diagn\u00f3stico del S\u00edndrome de Gilbert"},"content":{"rendered":"<div class=\"7ca9444b8380138fe077da07353677a4\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><span class=\"hps\">El s\u00edndrome de Gilbert<\/span>\u00a0<span class=\"hps\">es un trastorno gen\u00e9tico<\/span>\u00a0<span class=\"hps\">y una condici\u00f3n<\/span>\u00a0<span class=\"hps\">autos\u00f3mica recesiva<\/span>\u00a0<span class=\"hps\">caracterizada por<\/span>\u00a0<span class=\"hps\">ictericia<\/span>\u00a0<span class=\"hps\">intermitente<\/span>, en ausencia de\u00a0<span class=\"hps\">hem\u00f3lisis<\/span>\u00a0<span class=\"hps\">o enfermedad hep\u00e1tica.<\/span><br \/>\n<!--more--><br \/>\n<span class=\"hps\">La<\/span>\u00a0<span class=\"hps\">hiperbilirrubinemia<\/span>\u00a0<span class=\"hps\">es leve.<\/span>\u00a0<span class=\"hps\">Por definici\u00f3n,<\/span>\u00a0<span class=\"hps\">los niveles de bilirrubina<\/span>\u00a0<span class=\"hps\">en el<\/span>\u00a0<span class=\"hps\">s\u00edndrome de Gilbert<\/span>\u00a0<span class=\"hps\">son inferiores a<\/span>\u00a0<span class=\"hps\">6 mg\/<\/span><span class=\"hps\">dl<\/span>,\u00a0<span class=\"hps\">aunque la mayor\u00eda de<\/span>\u00a0<span class=\"hps\">los pacientes presentan<\/span>\u00a0<span class=\"hps\">niveles inferiores a<\/span>\u00a0<span class=\"hps\">3 mg\/dL<\/span>.\u00a0<span class=\"hps\">El s\u00edndrome de Gilbert<\/span>\u00a0<span class=\"hps\">es el resultado de<\/span>\u00a0<span class=\"hps\">una mutaci\u00f3n gen\u00e9tica<\/span>\u00a0<span class=\"hps\">en la regi\u00f3n promotora<\/span>\u00a0<span class=\"hps\">de un gen<\/span>\u00a0<span class=\"hps\">para la<\/span>\u00a0<span class=\"hps\">enzima<\/span>\u00a0<span class=\"hps\">UGT1A<\/span>\u00a0<span class=\"hps\">(bilirrubina<\/span>-uridina\u00a0<span class=\"hps\">difosfato<\/span>\u00a0<span class=\"hps\">glucuronil<\/span>\u00a0<span class=\"hps\">transferasa<\/span>).<br \/>\n<span class=\"hps\">Un diagn\u00f3stico presuntivo<\/span>\u00a0<span class=\"hps\">puede<\/span>\u00a0<span class=\"hps\">hacerse<\/span>\u00a0<span class=\"hps\">en pacientes con<\/span>\u00a0<span class=\"hps\">las siguientes caracter\u00edsticas:<\/span><\/p>\n<ul>\n<li><span class=\"hps\">Hiperbilirrubinemia no conjugada<\/span>\u00a0<span class=\"hps\">en<\/span><span class=\"hps\">\u00a0pruebas<\/span>\u00a0<span class=\"hps\">repetidas<\/span><\/li>\n<li><span class=\"hps\">R<\/span><span class=\"hps\">ecuento<\/span><span class=\"hps\">\u00a0sangu\u00edneo completo<\/span><span class=\"hps\">,<\/span>\u00a0<span class=\"hps\">frotis de sangre<\/span>,\u00a0<span class=\"hps\">y<\/span>\u00a0<span class=\"hps\">de reticulocitos<\/span><span class=\"hps\"> normales<\/span><\/li>\n<li><span class=\"hps\">Pruebas de funci\u00f3n hep\u00e1tica<\/span>\u00a0<span class=\"hps\">normal<\/span>\u00a0<span class=\"hps atn\">(<\/span><span class=\"hps\">concentraciones de\u00a0<\/span>transaminasas\u00a0<span class=\"hps\">en plasma<\/span>\u00a0<span class=\"hps\">y\u00a0<\/span><span class=\"hps\">fosfatasa alcalina<\/span>)<\/li>\n<\/ul>\n<p><span class=\"hps\">El diagn\u00f3stico<\/span>\u00a0<span class=\"hps\">es<\/span>\u00a0<span class=\"hps\">definitivo en pacientes<\/span>\u00a0<span class=\"hps\">que contin\u00faan con<\/span>\u00a0<span class=\"hps\">estudios<\/span>\u00a0<span class=\"hps\">de laboratorio normales<\/span>\u00a0<span class=\"hps\">(que no sea<\/span>\u00a0<span class=\"hps\">la elevaci\u00f3n de la<\/span>\u00a0<span class=\"hps\">bilirrubina plasm\u00e1tica<\/span>) durante\u00a0<span class=\"hps\">los pr\u00f3ximos 12 a<\/span>\u00a0<span class=\"hps\">18 meses.<\/span>\u00a0<span class=\"hps\">Como se mencion\u00f3 anteriormente<\/span>,\u00a0<span class=\"hps\">el diagn\u00f3stico<\/span>\u00a0<span class=\"hps\">tambi\u00e9n es apoyada por<\/span>\u00a0<span class=\"hps\">la observaci\u00f3n de<\/span>\u00a0<span class=\"hps\">un aumento en<\/span>\u00a0<span class=\"hps\">la concentraci\u00f3n<\/span>\u00a0<span class=\"hps\">de bilirrubina plasm\u00e1tica<\/span>\u00a0<span class=\"hps\">seguido de un descenso de l\u00edpidos<\/span>,\u00a0<span class=\"hps\">dieta<\/span>\u00a0de\u00a0400\u00a0<span class=\"hps\">kcal<\/span>\u00a0<span class=\"hps\">o despu\u00e9s de la<\/span>\u00a0<span class=\"hps\">administraci\u00f3n de \u00e1cido nicot\u00ednico<\/span>\u00a0<span class=\"hps\">por v\u00eda intravenosa<\/span>.\u00a0<span class=\"hps\">Sin embargo, estas<\/span>\u00a0<span class=\"hps\">pruebas de provocaci\u00f3n<\/span>\u00a0<span class=\"hps\">rara vez son necesarias<\/span>\u00a0<span class=\"hps\">en la pr\u00e1ctica cl\u00ednica<\/span>.<br \/>\n<span class=\"hps\">Las pruebas gen\u00e9ticas pueden<\/span>\u00a0<span class=\"hps\">confirmar el diagn\u00f3stico<\/span>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Bibliograf\u00eda:<\/strong><\/p>\n<ol>\n<li>Claridge LC, Armstrong MJ, Booth C, Gill PS. Gilbert&#8217;s syndrome. BMJ. 2011 Apr 19;342:d2293. doi: 10.1136\/bmj.d2293. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21508045\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert&#8217;s syndrome. N Engl J Med. 1995 Nov 2;333(18):1171-5. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7565971\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Creado Jul 5, 2011.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>El s\u00edndrome de Gilbert\u00a0es un trastorno gen\u00e9tico\u00a0y una condici\u00f3n\u00a0autos\u00f3mica recesiva\u00a0caracterizada por\u00a0ictericia\u00a0intermitente, en ausencia de\u00a0hem\u00f3lisis\u00a0o enfermedad hep\u00e1tica.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[53],"tags":[123,13,1203,5,4],"class_list":["post-2426","post","type-post","status-publish","format-standard","hentry","category-gastroenterology","tag-diagnosis","tag-diagnostico","tag-gilbert","tag-sindrome","tag-syndrome"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/comments?post=2426"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2426\/revisions"}],"predecessor-version":[{"id":9330,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2426\/revisions\/9330"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/media?parent=2426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/categories?post=2426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/tags?post=2426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}