{"id":2441,"date":"2010-12-13T14:25:52","date_gmt":"2010-12-13T14:25:52","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/reugp\/"},"modified":"2025-05-14T19:08:28","modified_gmt":"2025-05-14T19:08:28","slug":"reugp","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/es\/reugp\/","title":{"rendered":"Diagn\u00f3stico del S\u00edndrome de Goodpasture"},"content":{"rendered":"<div class=\"7ca9444b8380138fe077da07353677a4\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><span class=\"long_text\">El s\u00edndrome de Goodpasture es una enfermedad poco frecuente, caracterizada por hemorragia pulmonar, glomerulonefritis y anticuerpos antiglomerular membrana basal.<\/span><br \/>\n<!--more--><br \/>\n<span class=\"long_text\">La<\/span><span class=\"long_text\">\u00a0enfermedad<\/span><span class=\"long_text\">\u00a0antimembrana basal glomerular (anti-MBG) o s\u00edndrome de Goodpasture se caracteriza por hemorragia pulmonar, glomerulonefritis, o ambos.\u00a0Lo patognom\u00f3nico para el s\u00edndrome de Goodpasture son autoanticuerpos contra la membrana basal glomerular renal y<\/span><span class=\"long_text\">\u00a0alveolar<\/span><span class=\"long_text\">\u00a0pulmonar.\u00a0El autoant\u00edgeno espec\u00edfico es el dominio\u00a0<\/span><span class=\"long_text\">no colagenoso\u00a0<\/span><span class=\"long_text\">de 235 amino\u00e1cidos carboxi-terminal del col\u00e1geno tipo IV.\u00a0El an\u00e1lisis de orina de los sujetos afectados revela proteinuria, gl\u00f3bulos rojos dism\u00f3rficos, gl\u00f3bulos blancos, gl\u00f3bulos rojos y cilindros granulares.\u00a0Las pruebas de diagn\u00f3stico incluye la detecci\u00f3n de anticuerpos anti-MBG.\u00a0En los casos en los que\u00a0<\/span><span class=\"long_text\">ocurre s\u00f3lo<\/span><span class=\"long_text\">\u00a0la hemorragia alveolar difusa, los anticuerpos pueden<\/span><span class=\"long_text\">\u00a0no<\/span><span class=\"long_text\">\u00a0estar presentes.\u00a0En esos casos, el diagn\u00f3stico se establece mediante la demostraci\u00f3n de inmunofluorescencia lineal en el tejido pulmonar.<\/span><br \/>\n<span class=\"long_text\">Los pacientes que presentan afectaci\u00f3n renal a menudo tienen comienzo brusco de oliguria o anuria, hematuria, y anemia.\u00a0La biopsia renal puede revelar medialunas en m\u00e1s del 50% de los glom\u00e9rulos en la microscop\u00eda de luz (ML).\u00a0La inmunofluorescencia muestra dep\u00f3sitos lineales de IgG a lo largo de los capilares glomerulares y, en ocasiones los t\u00fabulos distales.\u00a0En raras ocasiones, IgA o IgM pueden estar presentes.\u00a0Los anticuerpos anti-MBG tambi\u00e9n se detectan en el suero mediante inmunofluorescencia o ELISA.\u00a0Muchos pacientes tambi\u00e9n presentan resultados positivos para ANCA, en particular ANCAp \/ MPO.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Bibliograf\u00eda:<\/strong><\/p>\n<ol>\n<li>Kalluri R. Goodpasture syndrome. Kidney Int. 1999 Mar;55(3):1120-2.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10027952\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Salama AD, Levy JB, Lightstone L, Pusey CD. Goodpasture&#8217;s disease. Lancet. 2001 Sep 15;358(9285):917-20.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11567730\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Dec 13, 2010.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>El s\u00edndrome de Goodpasture es una enfermedad poco frecuente, caracterizada por hemorragia pulmonar, glomerulonefritis y anticuerpos antiglomerular membrana basal.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45],"tags":[123,13,1268,5,4],"class_list":["post-2441","post","type-post","status-publish","format-standard","hentry","category-rheumatology","tag-diagnosis","tag-diagnostico","tag-goodpasture","tag-sindrome","tag-syndrome"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/comments?post=2441"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2441\/revisions"}],"predecessor-version":[{"id":9345,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2441\/revisions\/9345"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/media?parent=2441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/categories?post=2441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/tags?post=2441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}