{"id":2443,"date":"2010-10-27T20:01:07","date_gmt":"2010-10-27T20:01:07","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/reuantibodies\/"},"modified":"2025-05-14T19:08:29","modified_gmt":"2025-05-14T19:08:29","slug":"reuantibodies","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/es\/reuantibodies\/","title":{"rendered":"Pruebas de Laboratorio Cl\u00ednico en Enfermedades Reum\u00e1ticas"},"content":{"rendered":"<div class=\"7ca9444b8380138fe077da07353677a4\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><span class=\"long_text\">El diagn\u00f3stico de las enfermedades reumatol\u00f3gicas se basa en la informaci\u00f3n cl\u00ednica, pruebas en sangre e im\u00e1genes, y en algunos casos en la histolog\u00eda.\u00a0Los an\u00e1lisis de sangre son \u00fatiles para confirmar el diagn\u00f3stico de sospecha cl\u00ednica y en monitorear la actividad de la enfermedad.\u00a0Las pruebas deben ser utilizados como complementos de una historia completa y un examen f\u00edsico.<\/span><br \/>\n<span class=\"long_text\"><!--more--><br \/>\n<strong>Reactantes de fase aguda<\/strong><br \/>\nLos reactantes de fase aguda son prote\u00ednas que se incrementan la concentraci\u00f3n plasm\u00e1tica (prote\u00ednas de fase aguda positiva) o disminuyen (<\/span><span class=\"long_text\">prote\u00ednas de fase aguda<\/span><span class=\"long_text\">\u00a0negativas) en al menos un 25% durante los estados inflamatorios.<br \/>\n<\/span><br \/>\n<span class=\"long_text\">Reactantes de fase aguda positivos<br \/>\n<\/span><\/p>\n<ul>\n<li><span class=\"long_text\">Alfa-1 antitripsina<\/span><\/li>\n<li><span class=\"long_text\">Ceruloplasmina<\/span><\/li>\n<li><span class=\"long_text\">C<\/span><span class=\"long_text\">omponentes<\/span><span class=\"long_text\">\u00a0del complemento<\/span><\/li>\n<li><span class=\"long_text\">Velocidad de sedimentaci\u00f3n globular (VSG) y prote\u00edna C-reactiva (PCR)<\/span><\/li>\n<li><span class=\"long_text\">Ferritina<\/span><\/li>\n<li><span class=\"long_text\">Fibrin\u00f3geno<\/span><\/li>\n<li><span class=\"long_text\">Haptoglobina<\/span><\/li>\n<li><span class=\"long_text\">Amiloide s\u00e9rico A<br \/>\n<\/span><\/li>\n<\/ul>\n<p><span class=\"long_text\"><br \/>\nReactantes de fase aguda negativos<\/span><\/p>\n<ul>\n<li><span class=\"long_text\">Alb\u00famina<\/span><\/li>\n<li><span class=\"long_text\">Transferrina<\/span><\/li>\n<li><span class=\"long_text\">Transtiretina (prealb\u00famina transportadora de tiroxina)<br \/>\n<\/span><\/li>\n<\/ul>\n<p><span class=\"long_text\"><br \/>\n<strong>Anticuerpos Antinucleares\u00a0<\/strong><br \/>\nLos anticuerpos antinucleares (ANA), dirigidos contra una variedad de ant\u00edgenos nucleares se han detectado en el suero de pacientes con muchas enfermedades reum\u00e1ticas y no reum\u00e1ticas, as\u00ed como en personas sanas.<\/span><br \/>\n<span class=\"long_text\"><br \/>\nSensibilidad y especificidad de anticuerpos antinucleares en diversas enfermedades del tejido conectivo<\/span><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td><strong>\u00a0<span class=\"long_text\">Enfermedad<\/span><\/strong><\/td>\n<td align=\"center\"><strong>\u00a0<span class=\"long_text\">Sensibilidad\u00a0 (%)<\/span><\/strong><\/td>\n<td align=\"center\"><strong>\u00a0<span class=\"long_text\">Especificidad (%)<\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Lupus eritematoso sist\u00e9mico<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">93-95<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">57<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Esclerodermia<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">85<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">54<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Polimiositis, dermatomiositis<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">61<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">63<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Artritis reumatoide<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">41<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">56<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">S\u00edndrome de Sj\u00f6gren<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">48<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">52<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Fen\u00f3meno de Raynaud<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">64<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">41<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Artritis cr\u00f3nica juvenil<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">57<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">39<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Artritis cr\u00f3nica juvenil con uve\u00edtis<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">80<\/span><\/td>\n<td align=\"center\">\u00a0<span class=\"long_text\">53<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"long_text\"><br \/>\nHay diferentes tipos de ANA en base a su ant\u00edgeno blanco, incluyendo el ADN de cadena simple (ssDNA) y de doble cadena compleja de prote\u00ednas de ADN (DNA de doble cadena), las histonas nucleares y las prote\u00ednas nucleares <\/span>no histonas, y el ARN.\u00a0El patr\u00f3n de tinci\u00f3n visto en la inmunofluorescencia indirecta (IFI) da una idea de la especificidad de los anticuerpos en la muestra.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td>\u00a0<span class=\"long_text\">Ant\u00edgeno<\/span><\/td>\n<td><span class=\"long_text\">Asociaci\u00f3n de Enfermedades<\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><strong>\u00a0<span class=\"long_text\">Homog\u00e9neo y difuso<\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Complejo ADN-histona (nucleosoma)<\/span><\/td>\n<td><span class=\"long_text\">LES (60%)<br \/>\nLupus inducido por f\u00e1rmacos (95%)<\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\"><strong>\u00a0<\/strong><span class=\"long_text\"><strong>Perif\u00e9rico \u00a0<\/strong><br \/>\n<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">dsDNA<\/span><\/td>\n<td><span class=\"long_text\">LES<\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\">\u00a0<strong><span class=\"long_text\">Moteado<\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">ARN polimerasa\u00a0<\/span><span class=\"long_text\">tipo\u00a0<\/span><span class=\"long_text\">II y III<\/span><\/td>\n<td><span class=\"long_text\">Esclerosis sist\u00e9mica<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">RNP<\/span><\/td>\n<td><span class=\"long_text\">EMTC (100%)<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Scl-70<\/span><\/td>\n<td><span class=\"long_text\">Esclerosis sist\u00e9mica (15% -70%)<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Sm<\/span><span class=\"long_text\"><br \/>\n<\/span><\/td>\n<td><span class=\"long_text\">LES (25% -30%)<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">SS-A\u00a0<\/span><\/td>\n<td><span class=\"long_text\">S\u00edndrome de Sj\u00f6gren (8% -70%)<br \/>\nLES (35% -40%)<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">SS-B<\/span><\/td>\n<td><span class=\"long_text\">S\u00edndrome de Sj\u00f6gren (14% -60%)<br \/>\nLES (15%)<\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\">\u00a0<strong><span class=\"long_text\">Nucleolar<\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">Nucleolar RNA, polimerasa 1 ARN<\/span><\/td>\n<td><span class=\"long_text\">Esclerosis sist\u00e9mica<\/span><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">PM-SCL<\/span><\/td>\n<td><span class=\"long_text\">Polimiositis<\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\">\u00a0<strong><span class=\"long_text\">Centr\u00f3mero<\/span><\/strong><\/td>\n<\/tr>\n<tr>\n<td>\u00a0<span class=\"long_text\">CENP<\/span><\/td>\n<td><span class=\"long_text\">Esclerodermia limitada<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"long_text\">EMTC, enfermedad mixta del tejido conectivo, LES, lupus eritematoso sist\u00e9mico.<br \/>\n<\/span><\/p>\n<p><span class=\"long_text\"><strong>Factor reumatoide\u00a0<\/strong><br \/>\nEl factor reumatoide (FR) indica autoanticuerpos que se dirigen contra la porci\u00f3n Fc de la IgG. El FR se detecta en una amplia variedad de enfermedades reum\u00e1ticas y no reum\u00e1ticas.<br \/>\nCondiciones reum\u00e1ticas (sensibilidad)<br \/>\n<\/span><\/p>\n<ul>\n<li><span class=\"long_text\">Crioglobulinemia (40% -100%)<\/span><\/li>\n<li><span class=\"long_text\">Polimiositis y dermatomiositis (5% -10%)<\/span><\/li>\n<li><span class=\"long_text\">Artritis reumatoide (50% -90%)<\/span><\/li>\n<li><span class=\"long_text\">S\u00edndrome de Sj\u00f6gren (75% -95%)<\/span><\/li>\n<li><span class=\"long_text\">Lupus eritematoso sist\u00e9mico (15% -35%)<\/span><\/li>\n<li><span class=\"long_text\">Esclerosis sist\u00e9mica (20% -30%)<\/span><\/li>\n<\/ul>\n<p><span class=\"long_text\">Condiciones no reum\u00e1ticas<br \/>\n<\/span><\/p>\n<ul>\n<li><span class=\"long_text\">Endocarditis bacteriana<\/span><\/li>\n<li><span class=\"long_text\">Infecciones<\/span>\n<ul>\n<li><span class=\"long_text\">Hepatitis<\/span><\/li>\n<li><span class=\"long_text\">Lepra<\/span><\/li>\n<li><span class=\"long_text\">Par\u00e1sitos<\/span><\/li>\n<li><span class=\"long_text\">S\u00edfilis<\/span><\/li>\n<li><span class=\"long_text\">Tuberculosis<\/span><\/li>\n<\/ul>\n<\/li>\n<li><span class=\"long_text\">Malignidad<\/span><\/li>\n<li><span class=\"long_text\">Enfermedad pulmonar<\/span>\n<ul>\n<li><span class=\"long_text\">Fibrosis pulmonar intersticial<\/span><\/li>\n<li><span class=\"long_text\">Sarcoidosis<\/span><\/li>\n<li><span class=\"long_text\">Silicosis<\/span><\/li>\n<\/ul>\n<\/li>\n<li><span class=\"long_text\">Cirrosis biliar primaria<\/span><\/li>\n<\/ul>\n<p><span class=\"long_text\"><br \/>\n<strong>Otros anticuerpos\u00a0<\/strong><br \/>\nLos anticuerpos en suero puede ayudar a distinguir algunas de otras causas, tales como:<br \/>\n<\/span><\/p>\n<ul>\n<li><span class=\"long_text\">Anticuerpos<\/span><span class=\"long_text\">\u00a0anti membrana basal<\/span><span class=\"long_text\">\u00a0glomerular<\/span><span class=\"long_text\">: s\u00edndrome de Goodpasture<\/span><\/li>\n<li><span class=\"long_text\">Anticuerpos de doble cadena de ADN y la reducci\u00f3n de los niveles s\u00e9ricos de complemento: LES<\/span><\/li>\n<li><span class=\"long_text\">Anticuerpos Citoplasm\u00e1ticos Antineutr\u00f3filo<\/span><span class=\"long_text\">\u00a0(ANCA) dirigidos contra la proteinasa-3 (PR3-ANCA o citoplasm\u00e1tica ANCA [ANCA-c]): granulomatosis de Wegener<\/span><\/li>\n<li><span class=\"long_text\">Anticuerpos Citoplasm\u00e1ticos Antineutr\u00f3filo<\/span><span class=\"long_text\">\u00a0dirigidos contra la mieloperoxidasa (MPO-ANCA, o ANCA perinuclear [ANCA-p]): poliange\u00edtis microsc\u00f3pica\u00a0<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Bibliograf\u00eda:<\/strong><\/p>\n<ol>\n<li>Morley JJ, Kushner I. Serum C-reactive protein levels in disease. Ann N Y Acad Sci. 1982, 389: 406-418.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6953917\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Sheldon J. Laboratory testing in autoimmune rheumatic diseases. Best Pract Res Clin Rheumatol. 2004, 18: 249-269. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15158740\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Hoffman GS, Specks U. Antineutrophil cytoplasmic antibodies. Arthritis Rheum. 1998, 41: 1521-1537.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9751084\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Kerr GS, Fleisher TA, Hallahan CW, et al: Limited prognostic value of changes in antineutrophil cytoplasmic antibody titer in patients with Wegener&#8217;s granulomatosis. Arthritis Rheum. 1993, 36: 365-371.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8452581\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Colglazier CL, Sutej PG. Laboratory testing in the rheumatic diseases: a practical review. South Med J. 2005 Feb;98(2):185-91.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15759949\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<br \/>\n<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Creado: Nov 1, 2010<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>El diagn\u00f3stico de las enfermedades reumatol\u00f3gicas se basa en la informaci\u00f3n cl\u00ednica, pruebas en sangre e im\u00e1genes, y en algunos casos en la histolog\u00eda.\u00a0Los an\u00e1lisis de sangre son \u00fatiles para confirmar el diagn\u00f3stico de sospecha cl\u00ednica y en monitorear la actividad de la enfermedad.\u00a0Las pruebas deben ser utilizados como complementos de una historia completa y [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45],"tags":[1280,1279,1278,490,489,1277,1276,938,937,1275,1274,269],"class_list":["post-2443","post","type-post","status-publish","format-standard","hentry","category-rheumatology","tag-anca","tag-ancas","tag-antineutrophil-cytoplasmic-antibody","tag-clinical","tag-clinico","tag-diseases","tag-enfermedades","tag-laboratorio","tag-laboratory","tag-reumaticas","tag-rheumatic","tag-testing"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/comments?post=2443"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2443\/revisions"}],"predecessor-version":[{"id":9347,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/2443\/revisions\/9347"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/media?parent=2443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/categories?post=2443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/tags?post=2443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}