{"id":93,"date":"2009-02-28T15:39:48","date_gmt":"2009-02-28T15:39:48","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/dbtinsulin\/"},"modified":"2025-05-14T19:11:56","modified_gmt":"2025-05-14T19:11:56","slug":"dbtinsulin","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/es\/dbtinsulin\/","title":{"rendered":"Farmacocin\u00e9tica de los Diferentes Tipos de Insulina"},"content":{"rendered":"<div class=\"7ca9444b8380138fe077da07353677a4\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><figure id=\"attachment_6715\" aria-describedby=\"caption-attachment-6715\" style=\"width: 544px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin_es.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6715 size-full\" src=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin_es.jpg\" alt=\"Farmacocin\u00e9tica de los Diferentes Tipos de Insulina\" width=\"544\" height=\"354\" srcset=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin_es.jpg 544w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin_es-300x195.jpg 300w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/insulin_es-461x300.jpg 461w\" sizes=\"auto, (max-width: 544px) 100vw, 544px\" \/><\/a><figcaption id=\"caption-attachment-6715\" class=\"wp-caption-text\">Farmacocin\u00e9tica de los Diferentes Tipos de Insulina<\/figcaption><\/figure><\/p>\n<p>Cada preparaci\u00f3n de insulina tiene un perfil farmacocin\u00e9tico diferente, es decir, inicio, efecto m\u00e1ximo y duraci\u00f3n.<br \/>\n<!--more--><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td width=\"377\"><\/td>\n<td style=\"text-align: center;\" colspan=\"3\" width=\"353\"><strong>Tiempo de Acci\u00f3n<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"377\"><strong>Preparaci\u00f3n<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"93\"><strong>Comienzo, h<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"64\"><strong>Pico, h<\/strong><\/td>\n<td style=\"text-align: center;\" width=\"156\"><strong>Duraci\u00f3n Efectiva, h<\/strong><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"751\">Acci\u00f3n corta, subcut\u00e1nea<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Lispro<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0,25<\/td>\n<td style=\"text-align: center;\" width=\"64\">0,5\u20131,5<\/td>\n<td style=\"text-align: center;\" width=\"156\">3\u20134<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Asp\u00e1rtica<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0,25<\/td>\n<td style=\"text-align: center;\" width=\"64\">0,5\u20131,5<\/td>\n<td style=\"text-align: center;\" width=\"156\">3\u20134<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Glulisina<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0,25<\/td>\n<td style=\"text-align: center;\" width=\"64\">0,5\u20131,5<\/td>\n<td style=\"text-align: center;\" width=\"156\">3\u20134<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Regular<\/td>\n<td style=\"text-align: center;\" width=\"93\">0,5\u20131,0<\/td>\n<td style=\"text-align: center;\" width=\"64\">2\u20133<\/td>\n<td style=\"text-align: center;\" width=\"156\">4\u20136<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"751\">Acci\u00f3n corta inhalada<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Insulina regular inhalada<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0,25<\/td>\n<td style=\"text-align: center;\" width=\"64\">0,5\u20131,5<\/td>\n<td style=\"text-align: center;\" width=\"156\">4\u20136<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"751\">Acci\u00f3n larga<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 NPH<\/td>\n<td style=\"text-align: center;\" width=\"93\">1\u20134<\/td>\n<td style=\"text-align: center;\" width=\"64\">6\u201310<\/td>\n<td style=\"text-align: center;\" width=\"156\">10\u201316<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Detemir<\/td>\n<td style=\"text-align: center;\" width=\"93\">1\u20134<\/td>\n<td style=\"text-align: center;\" width=\"64\">\u2014<em><sup>a<\/sup><\/em><\/td>\n<td style=\"text-align: center;\" width=\"156\">12\u201320<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 Glargina<\/td>\n<td style=\"text-align: center;\" width=\"93\">1\u20134<\/td>\n<td style=\"text-align: center;\" width=\"64\">\u2014<em><sup>a<\/sup><\/em><\/td>\n<td style=\"text-align: center;\" width=\"156\">24<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\" width=\"751\">Combinaciones de Insulina<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0 \u00a075\/25\u201375% lispro protamina, 25% lispro<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0.25<\/td>\n<td style=\"text-align: center;\" width=\"64\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"text-align: center;\" width=\"156\">Up to 10\u201316<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 70\/30\u201370% asp\u00e1rtica protamina, 30% asp\u00e1rtica<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0.25<\/td>\n<td style=\"text-align: center;\" width=\"64\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"text-align: center;\" width=\"156\">Up to 10\u201316<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 50\/50\u201350% lispro protamina, 50% lispro<\/td>\n<td style=\"text-align: center;\" width=\"93\">&lt;0.25<\/td>\n<td style=\"text-align: center;\" width=\"64\">1.5 h<em><sup>b<\/sup><\/em><\/td>\n<td style=\"text-align: center;\" width=\"156\">Up to 10\u201316<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 70\/30\u201370% NPH, 30% insulina regular<\/td>\n<td style=\"text-align: center;\" width=\"93\">0.5\u20131<\/td>\n<td style=\"text-align: center;\" width=\"64\">Dual<\/td>\n<td style=\"text-align: center;\" width=\"156\">10\u201316<\/td>\n<\/tr>\n<tr>\n<td width=\"377\">\u00a0\u00a0 50\/50\u201350% NPH, 50% insulina regular<\/td>\n<td style=\"text-align: center;\" width=\"93\">0.5\u20131<\/td>\n<td style=\"text-align: center;\" width=\"64\">Dual<\/td>\n<td style=\"text-align: center;\" width=\"156\">10\u201316<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em><sup>a<\/sup><\/em>La Glargina tiene actividad pico m\u00ednima; la detemir tiene una peque\u00f1a actividad pico a los 6\u201314 h.<br \/>\n<em><sup>b<\/sup><\/em>Dual: dos picos; uno a las 2\u20133 h; y el segundo algunas horas m\u00e1s tarde.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Bibliograf\u00eda:\u00a0<\/strong><\/p>\n<ol>\n<li>Hirsch IB. Insulin analogues.\u00a0N Engl J Med. 2005 Jan 13;352(2):174-83.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15647580\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>DeWitt DE, Hirsch IB. Outpatient insulin therapy in type 1 and type 2 diabetes mellitus: scientific review. JAMA. 2003 May 7;289(17):2254-64.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12734137\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Jonassen I, Havelund S, Ribel U, et al. Insulin degludec is a new generation ultra-long acting basal insulin with a unique mechanism of protraction based on multi-hexamer formation. Diabetes. 2010;59(Suppl 1):A11.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Creado: Dic 31, 2008<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Cada preparaci\u00f3n de insulina tiene un perfil farmacocin\u00e9tico diferente, es decir, inicio, efecto m\u00e1ximo y duraci\u00f3n.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[626],"tags":[2001,211,2000,1999,1998,1997,1996,1995,1994,1993,1992,2002],"class_list":["post-93","post","type-post","status-publish","format-standard","hentry","category-diabetes","tag-detemir","tag-diabetes","tag-farmacocinetica","tag-glargina","tag-glargine","tag-glulisina","tag-insulin","tag-lisproglulisine","tag-nph","tag-pharmacokinetics","tag-pharmacology","tag-preparations"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":7,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/93\/revisions"}],"predecessor-version":[{"id":9397,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/posts\/93\/revisions\/9397"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/categories?post=93"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/es\/wp-json\/wp\/v2\/tags?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}