Names and definitions of vasculitis adopted by the Chapel Hill Consensus Conference

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Names and definitions of vasculitis adopted by the Chapel Hill Consensus Conference on the nomenclature of systemic vasculitis

  1. Polyarteritis nodosa (PAN): Necrotizing inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, capillaries or venules.
  2. Wegener´s granulomatosis (WG): Granulomatous inflammation involving the respiratory tract, and necrotizing vasculitis affecting small to medium-sized vessels, e. g. capillaries, venules, arterioles and arteries. Necrotizing glomerulonephritis is common.
  3. Churg-Strauss syndrome (CSS): Eosinophil-rich and granulomatous inflammation involving the respiratory tract and necrotizing vasculitis affecting small to medium-sized vessels, and associated with asthma and blood eosinophilia.
  4. Microscopic polyangiitis (MSA): Necrotizing vasculitis with few or no immune deposits affecting small vessels, i.e. capillaries, venules or arterioles. Necrotizing arteritis of small and medium-sized arteries may be present. Necrotizing glomerulonephritis is very common. Pulmonary capillaritis often occurs.

 

 

References:

  1. Bruce IN, Bell AL. A comparison of two nomenclature systems for primary systemic vasculitis. Br J Rheumatol. 1997 Apr;36(4):453-8. [Medline]

Created: May 29, 2005