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EULAR/ACR New Classification Criteria for Systemic Lupus Erythematosus (SLE)

The new EULAR/ACR classification criteria use anti-nuclear antibodies (ANA) as an entry criterion. (Non-infectious) fever is the one new criterion. All criteria items now have individual weights (from 2 to 10) and are structured in domains, within which only the highest item is counted. There is one common attribution rule, counting criteria only if there is no more likely alternative explanation. Ten points are sufficient for classification. The new criteria have reached a sensitivity of 96.1% and a specificity of 93.4%. Continue reading “EULAR/ACR New Classification Criteria for Systemic Lupus Erythematosus (SLE)”

Criteria for the Classification of Systemic Sclerosis (Scleroderma)

1980 Criteria for the Classification of Systemic Sclerosis

The American College of Rheumatology (former American Rheumatism Association – ARA) has defined criteria, that are 97 % sensitive and 98 % specific for systemic sclerosis (SSc) as follows:

Major criterion:

Classification Criteria for the Diagnosis of Systemic Lupus Erythematosus (SLE)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown cause that can affect virtually any organ of the body. Immunologic abnormalities, especially the production of a number of antinuclear antibodies (ANA), are a prominent feature of the disease. Continue reading “Classification Criteria for the Diagnosis of Systemic Lupus Erythematosus (SLE)”

Relative Potencies of Systemic Glucocorticoids

Glucocorticosteroids are a product of the adrenal cortex and perform a staggering number of physiological effects essential for life. Their clinical use is largely predicated on their anti-inflammatory and immunosuppressive properties.
Continue reading “Relative Potencies of Systemic Glucocorticoids”

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