{"id":10223,"date":"2023-11-24T20:34:04","date_gmt":"2023-11-24T20:34:04","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=10223"},"modified":"2025-12-30T19:11:09","modified_gmt":"2025-12-30T19:11:09","slug":"premature-ovarian-insufficiency","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/premature-ovarian-insufficiency\/","title":{"rendered":"Diagnosis and Initial Evaluation of Premature Ovarian Insufficiency (POI)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Premature ovarian insufficiency (POI), by definition, occurs when a woman has her last menstrual period before the age\u00a0of 40, because of variable, and most often permanent ovarian dysfunction. It presents as hypergonadotropic hypogonadism with peripheral amenorrhea. It has a prevalence of 1-2%, but in women under 20 years its prevalence is one\u00a0case in every 10,000 women. POI is a devastating diagnosis for women of reproductive age. Many conditions can lead to POI, but it is most commonly idiopathic, and it has a variable clinical presentation. It has serious health consequences,\u00a0including psychological disorders such as anxiety or depression, infertility, osteoporosis, autoimmune disorders, cardiovascular diseases, and an increased risk of mortality.<!--more--><\/p>\n<p><strong>Diagnosis and initial evaluation of POI in adolescents (ACOG)\u00a0<\/strong><\/p>\n<p>Diagnosis of primary ovarian insufficiency<\/p>\n<ol>\n<li>Menstrual irregularity for at least 3 consecutive months<\/li>\n<li>Follicle-Stimulating Hormone (FSH) and Oestradiol (E2) Levels: two randomized tests at least 1 month apart<\/li>\n<li>Prolactin test (PRL) and thyroid function test (TSH and free T4)<\/li>\n<li>Beta-human Chorionic Gonadotropin (\u00df-hCG) *<\/li>\n<\/ol>\n<p>If diagnosis is confirmed<\/p>\n<ol>\n<li>Karyotype<\/li>\n<li>FMR1 Premutation<\/li>\n<li>Adrenal antibodies: 21-hydroxylase (CYP21) by immunoprecipitation or indirect immunofluorescence<\/li>\n<li>Pelvic ultrasonography<\/li>\n<\/ol>\n<p>* levels that rule out pregnancy.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Stuenkel CA, Gompel A. Primary Ovarian Insufficiency. N Engl J Med. 2023 Jan 12;388(2):154-163. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36630623\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Committee opinion no. 605: primary ovarian insufficiency in adolescents and young women. Obstet Gynecol. 2014 Jul;124(1):193-197. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24945456\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Nov 17, 2023.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[87],"tags":[1938,123,13,161,160,2630,671,707,2631,2632,2629],"class_list":["post-10223","post","type-post","status-publish","format-standard","hentry","category-obstetrics-gynecology","tag-adolescents","tag-diagnosis","tag-diagnostico","tag-evaluacion","tag-evaluation","tag-insufficiency","tag-insuficiencia","tag-ovarian","tag-ovarica","tag-prematura","tag-premature"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=10223"}],"version-history":[{"count":8,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10223\/revisions"}],"predecessor-version":[{"id":10236,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10223\/revisions\/10236"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=10223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=10223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=10223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}