{"id":10237,"date":"2023-12-14T20:56:18","date_gmt":"2023-12-14T20:56:18","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=10237"},"modified":"2025-12-30T19:09:58","modified_gmt":"2025-12-30T19:09:58","slug":"budd-chiari-syndrome","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/","title":{"rendered":"Risk Factors of Budd-Chiari Syndrome"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Primary Budd-Chiari syndrome is characterized by a blocked hepatic venous outflow tract at various levels from small hepatic veins to inferior vena cava, resulting from thrombosis or its fibrous sequellae. This rare disease affects mainly young adults. Multiple risk factors have been identified and are often combined in the same patient.<!--more--><\/p>\n<p>Proposed work-up for investing underlying risk factors of Budd-Chiari syndrome<br \/>\nA. In all patients<\/p>\n<ul>\n<li>Personal and familial history of recurrent spontaneous deep vein thrombosis<\/li>\n<li>Oral contraceptive use in female patients<\/li>\n<li>V617F JAK 2 mutation in peripheral blood granulocytes. When the mutation is undetected, bone marrow biopsy looking for clusters of dystrophic megacaryocytes (myeloproliferative diseases)<\/li>\n<li>Flow cytometry for CD55 and CD59 deficient blood cells (paroxysmal nocturnal hemoglobinuria)<\/li>\n<li>Activated protein C resistance. When present molecular test for Factor V Leiden mutation<\/li>\n<li>Molecular test for G20210A prothrombin gene mutation<\/li>\n<li>Lupus anticoagulant, anti beta2 glycoprotein-1 antibodies, anticardiolipin antibodies (antiphospholpid syndrome)<\/li>\n<\/ul>\n<p>B. In patients with no marked liver dysfunction (normal prothrombin- level)<\/p>\n<ul>\n<li>Protein C, protein S and antithrombin plasma levels<\/li>\n<li>Plasma homocystein levels<\/li>\n<\/ul>\n<p>C- In patients with familial or personal history of recurrent spontaneous deep vein thrombosis: refer to blood coagulation specialist for a detailed study<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Garcia-Pag\u00e1n JC, Valla DC. Primary Budd-Chiari Syndrome. N Engl J Med. 2023 Apr 6;388(14):1307-1316. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37018494\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Valla DC. Primary Budd-Chiari syndrome. J Hepatol. 2009 Jan;50(1):195-203. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19012988\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Dec 14, 2023.<\/p>\n<p>&nbsp;<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[2634,2635,1893,1894,836,767,5,4],"class_list":["post-10237","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-budd","tag-chiari","tag-factores","tag-factors","tag-riesgo","tag-risk","tag-sindrome","tag-syndrome"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Risk Factors of Budd-Chiari Syndrome - MedicalCRITERIA.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[:es]Factores de Riesgo del S\u00edndrome de Budd-Chiari[:en]Risk Factors of Budd-Chiari Syndrome[:] - MedicalCRITERIA.com\" \/>\n<meta property=\"og:description\" content=\"Sorry, this entry is only available in Espa\u00f1ol.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"MedicalCRITERIA.com\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/medicalcriteria\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-14T20:56:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-30T19:09:58+00:00\" \/>\n<meta name=\"author\" content=\"Guillermo Firman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Guillermo Firman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/\"},\"author\":{\"name\":\"Guillermo Firman\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#\\\/schema\\\/person\\\/ead6734a2f20659131388ba822c7078c\"},\"headline\":\"Risk Factors of Budd-Chiari Syndrome\",\"datePublished\":\"2023-12-14T20:56:18+00:00\",\"dateModified\":\"2025-12-30T19:09:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/\"},\"wordCount\":531,\"publisher\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#organization\"},\"keywords\":[\"Budd\",\"Chiari\",\"factores\",\"Factors\",\"riesgo\",\"Risk\",\"sindrome\",\"Syndrome\"],\"articleSection\":[\"Hematology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/\",\"url\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/\",\"name\":\"[:es]Factores de Riesgo del S\u00edndrome de Budd-Chiari[:en]Risk Factors of Budd-Chiari Syndrome[:] - MedicalCRITERIA.com\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#website\"},\"datePublished\":\"2023-12-14T20:56:18+00:00\",\"dateModified\":\"2025-12-30T19:09:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/budd-chiari-syndrome\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Risk Factors of Budd-Chiari Syndrome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#website\",\"url\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/\",\"name\":\"MedicalCRITERIA.com\",\"description\":\"Unifying Concepts\",\"publisher\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#organization\",\"name\":\"MedicalCRITERIA.com\",\"alternateName\":\"Criterios M\u00e9dicos\",\"url\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/cropped-mc_1024x500.png\",\"contentUrl\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/wp-content\\\/uploads\\\/2025\\\/03\\\/cropped-mc_1024x500.png\",\"width\":600,\"height\":257,\"caption\":\"MedicalCRITERIA.com\"},\"image\":{\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/medicalcriteria\\\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/medicalcriteria.com\\\/web\\\/#\\\/schema\\\/person\\\/ead6734a2f20659131388ba822c7078c\",\"name\":\"Guillermo Firman\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g\",\"caption\":\"Guillermo Firman\"},\"sameAs\":[\"http:\\\/\\\/MedicalCRITERIA.com\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"[:es]Factores de Riesgo del S\u00edndrome de Budd-Chiari[:en]Risk Factors of Budd-Chiari Syndrome[:] - MedicalCRITERIA.com","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/","og_locale":"en_US","og_type":"article","og_title":"[:es]Factores de Riesgo del S\u00edndrome de Budd-Chiari[:en]Risk Factors of Budd-Chiari Syndrome[:] - MedicalCRITERIA.com","og_description":"Sorry, this entry is only available in Espa\u00f1ol.","og_url":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/","og_site_name":"MedicalCRITERIA.com","article_publisher":"https:\/\/www.facebook.com\/medicalcriteria\/","article_published_time":"2023-12-14T20:56:18+00:00","article_modified_time":"2025-12-30T19:09:58+00:00","author":"Guillermo Firman","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Guillermo Firman","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/#article","isPartOf":{"@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/"},"author":{"name":"Guillermo Firman","@id":"https:\/\/medicalcriteria.com\/web\/#\/schema\/person\/ead6734a2f20659131388ba822c7078c"},"headline":"Risk Factors of Budd-Chiari Syndrome","datePublished":"2023-12-14T20:56:18+00:00","dateModified":"2025-12-30T19:09:58+00:00","mainEntityOfPage":{"@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/"},"wordCount":531,"publisher":{"@id":"https:\/\/medicalcriteria.com\/web\/#organization"},"keywords":["Budd","Chiari","factores","Factors","riesgo","Risk","sindrome","Syndrome"],"articleSection":["Hematology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/","url":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/","name":"[:es]Factores de Riesgo del S\u00edndrome de Budd-Chiari[:en]Risk Factors of Budd-Chiari Syndrome[:] - MedicalCRITERIA.com","isPartOf":{"@id":"https:\/\/medicalcriteria.com\/web\/#website"},"datePublished":"2023-12-14T20:56:18+00:00","dateModified":"2025-12-30T19:09:58+00:00","breadcrumb":{"@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medicalcriteria.com\/web\/budd-chiari-syndrome\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/medicalcriteria.com\/web\/"},{"@type":"ListItem","position":2,"name":"Risk Factors of Budd-Chiari Syndrome"}]},{"@type":"WebSite","@id":"https:\/\/medicalcriteria.com\/web\/#website","url":"https:\/\/medicalcriteria.com\/web\/","name":"MedicalCRITERIA.com","description":"Unifying Concepts","publisher":{"@id":"https:\/\/medicalcriteria.com\/web\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medicalcriteria.com\/web\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/medicalcriteria.com\/web\/#organization","name":"MedicalCRITERIA.com","alternateName":"Criterios M\u00e9dicos","url":"https:\/\/medicalcriteria.com\/web\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/medicalcriteria.com\/web\/#\/schema\/logo\/image\/","url":"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2025\/03\/cropped-mc_1024x500.png","contentUrl":"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2025\/03\/cropped-mc_1024x500.png","width":600,"height":257,"caption":"MedicalCRITERIA.com"},"image":{"@id":"https:\/\/medicalcriteria.com\/web\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/medicalcriteria\/"]},{"@type":"Person","@id":"https:\/\/medicalcriteria.com\/web\/#\/schema\/person\/ead6734a2f20659131388ba822c7078c","name":"Guillermo Firman","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/24f0f68ba780b5b240680962755c6f75e6116e6667394a46e38b7b8fd0a62e9f?s=96&d=mm&r=g","caption":"Guillermo Firman"},"sameAs":["http:\/\/MedicalCRITERIA.com"]}]}},"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=10237"}],"version-history":[{"count":6,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10237\/revisions"}],"predecessor-version":[{"id":10248,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/10237\/revisions\/10248"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=10237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=10237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=10237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}