{"id":2111,"date":"2019-10-11T21:50:42","date_gmt":"2019-10-11T21:50:42","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=2249"},"modified":"2026-01-27T19:05:28","modified_gmt":"2026-01-27T19:05:28","slug":"zika","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/zika\/","title":{"rendered":"Features of Congenital Zika Syndrome"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The majority (50 to 80%) of Zika virus (ZIKV) infections are asymptomatic. Symptomatic ZIKV infection has an incubation period of 3 to 14 days and is a mild illness, with a duration of up to 1 week, that manifests as a rash, low-grade fever, arthralgia and myalgia, and conjunctivitis. Complications are infrequent, but when they occur, they are severe and may be fatal.<!--more--><\/p>\n<p>The ZIKV causes a spectrum of fetal and birth defects that extends beyond microcephaly and is distinct from other congenital infections in that its pathologic manifestations are restricted primarily to the central nervous system.<\/p>\n<p><strong>Features of Congenital Zika Syndrome<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 198px;\"><strong>Lesion Type<\/strong><\/td>\n<td style=\"width: 366px;\"><strong>Manifestations<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 574px;\" colspan=\"2\"><strong>Structural lesions<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Fetal brain disruption sequence*<\/td>\n<td style=\"width: 366px;\">Severe microcephaly, premature closure of fontanels, collapsed skull, overlapping sutures, redundant scalp skin<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Brain abnormalities<\/td>\n<td style=\"width: 366px;\">Cortical atrophy with decreased myelination, cerebellar hypoplasia Neuronal migration disorder &#8211; lissencephaly, agyria, pachygyria, polymicrogyria, heterotopia, dysgenesis of corpus callosum<br \/>\nCalcifications, mainly subcortical*<br \/>\nVentriculomegaly, increased posterior fossa and pericerebral spaces<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Ocular abnormalities<\/td>\n<td style=\"width: 366px;\">Pigmented retinal mottling*, chorioretinal atrophy*, macular scarring, glaucoma, optic nerve atrophy and abnormalities, intraocular calcifications<br \/>\nMicrophthalmia, anophthalmia<br \/>\nIris coloboma, lens subluxation, cataract<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Congenital contractures<\/td>\n<td style=\"width: 366px;\">Arthrogryposis, talipes equinovarus, hip dislocation<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Intrauterine growth restriction<\/td>\n<td style=\"width: 366px;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 574px;\" colspan=\"2\"><strong>Functional lesions<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Seizures<\/td>\n<td style=\"width: 366px;\"><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Pyramidal or extrapyramidal\u00a0abnormalities*<\/td>\n<td style=\"width: 366px;\">Body tone abnormalities (mainly hypertonia), swallowing disorder, movement abnormalities (dyskinesia, dystonia), hyperexcitability, impatient crying, sleep disorders<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 198px;\">Neurodevelopmental<br \/>\nabnormalities<\/td>\n<td style=\"width: 366px;\">Visual impairment (strabismus, nystagmus, vision loss)<br \/>\nHearing loss or deafness<br \/>\nDevelopmental delay<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* Lesions are rarely observed in other congenital infections.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Musso D, Ko AI, Baud D. Zika Virus Infection &#8211; After the Pandemic.\u00a0N Engl J Med. 2019 Oct 10;381(15):1444-1457. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31597021\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Lebov JF, Brown LM, MacDonald PDM, Robertson K, Bowman NM, Hooper SR, Becker-Dreps S. Review: Evidence of Neurological Sequelae in Children With Acquired Zika Virus Infection.\u00a0Pediatr Neurol. 2018 Aug;85:16-20. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30343688\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Bribes I, Nisole S. Zika Virus: A Tale of Two Lineages. Pathogens. 2025 Nov 12;14(11):1151. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41305388\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Oct 11, 2019.<br \/>\nUp-date Jan 27, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[40,43,44,41,5,4,42],"class_list":["post-2111","post","type-post","status-publish","format-standard","hentry","category-infetious-disease","tag-caracteristicas","tag-congenital","tag-congenito","tag-features","tag-sindrome","tag-syndrome","tag-zika"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2111"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2111\/revisions"}],"predecessor-version":[{"id":10595,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2111\/revisions\/10595"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}