{"id":2113,"date":"2019-10-02T20:07:10","date_gmt":"2019-10-02T20:07:10","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=2221"},"modified":"2026-01-28T18:59:16","modified_gmt":"2026-01-28T18:59:16","slug":"crohn","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/crohn\/","title":{"rendered":"Lennard-Jones Diagnostic Criteria of Crohn&#8217;s Disease (CD)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Once the clinical suspicion is established, the diagnosis is based on the combination of clinical, biochemical, endoscopic, histological and\/or radiological criteria.<!--more--><\/p>\n<p><strong>Lennard-Jones diagnostic criteria<\/strong><\/p>\n<p>Clinical criteria<\/p>\n<ul>\n<li>Recurrent abdominal pain<\/li>\n<li>Diarrhoea<\/li>\n<li>Weight loss<\/li>\n<li>Abdominal mass<\/li>\n<li>Fever or low-grade fever<\/li>\n<li>Perianal disease<\/li>\n<li>Fistulas<\/li>\n<li>Extraintestinal manifestations<\/li>\n<\/ul>\n<p>Radiological criteria<\/p>\n<ul>\n<li>Mucosal changes: aphthous ulcers, linear or rosebush thorn ulcers, longitudinal ulcers, inflammatory polyps, oedema of circular fold of small intestine<\/li>\n<li>Changes in calibre: stenosis, dilation, fistulas, asymmetry of lesions<\/li>\n<\/ul>\n<p>Endoscopic criteria<\/p>\n<ul>\n<li>Colonic involvement: aphthous ulcers, deep or serpiginous linear ulcerations, cobblestone appearance, stenosis, fistulous orifices, pseudopolyps and polyps; characteristically segmental lesions, of variable extension with mostly preserved rectum<\/li>\n<li>Ileal involvement: aphthous ulcers, ulcers and\/or stenosis<\/li>\n<\/ul>\n<p>Anatomo-pathological criteria<\/p>\n<ul>\n<li>Major: transmural inflammation, non-caseating granulomas, lymphoid aggregates without germinal centre<\/li>\n<li>Minor: intermittent inflammation, inflammation of the submucosa with conserved epithelial architecture, mucus retention with minimal inflammation, fissures<\/li>\n<\/ul>\n<p><strong>Defined disease:<\/strong> granulomas and other criteria or absence of granulomas and 3 criteria.<br \/>\n<strong>Probable disease:<\/strong> absence of granulomas and 2 criteria.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Reinisch S, Schweiger K, Pablik E, Collet-Fenetrier B, Peyrin-Biroulet L, Alfaro I, Pan\u00e9s J, Moayyedi P, Reinisch W. An index with improved diagnostic accuracy for the diagnosis of Crohn&#8217;s disease derived from the Lennard-Jones criteria.\u00a0Aliment Pharmacol Ther. 2016 Sep;44(6):601-11. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27466047\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Ballester Ferr\u00e9 MP, Bosc\u00e1-Watts MM, M\u00ednguez P\u00e9rez M. Crohn&#8217;s disease.\u00a0Med Clin (Barc). 2018 Jul 13;151(1):26-33. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29246562\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Pous S, Frasson M, Jim\u00e9nez R, Pami\u00e9s J, Puchades I, Llavador M, Garc\u00eda-Granero E, Nos P. Relevance of dynamic studies with magnetic resonance enterography in Crohn&#8217;s disease. Gastroenterol Hepatol. 2020 Apr;43(4):179-187. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32089377\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Sep 27, 2019.<br \/>\nUp-date Jan 28, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[53],"tags":[16,15,56,14,13,51,50,55,54,57],"class_list":["post-2113","post","type-post","status-publish","format-standard","hentry","category-gastroenterology","tag-criteria","tag-criterios","tag-crohn","tag-diagnostic","tag-diagnostico","tag-disease","tag-enfermedad","tag-jones","tag-lennard","tag-lennard-jones"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2113"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2113\/revisions"}],"predecessor-version":[{"id":10599,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2113\/revisions\/10599"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}