{"id":2162,"date":"2019-03-25T19:57:39","date_gmt":"2019-03-25T19:57:39","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=1533"},"modified":"2026-02-04T19:35:09","modified_gmt":"2026-02-04T19:35:09","slug":"lynch-syndrome","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/lynch-syndrome\/","title":{"rendered":"Guidelines for Diagnosis of the Lynch Syndrome"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The Lynch syndrome is the most common inherited syndrome associated with colorectal cancer, accounting for 3% of new diagnoses; it is also associated with extracolonic cancers, the most common of which is endometrial cancer.<br \/>\nThe Lynch syndrome phenotype includes a propensity for cancers of the proximal colon, poor tumor differentiation with mucinous or signet-ring cell histologic features or a medullary growth pattern, abundant infiltrating lymphocytes in the tumor, and synchronous and metachronous colorectal cancers.<!--more--><\/p>\n<p><strong> Guidelines for Diagnosis of the Lynch Syndrome<\/strong><\/p>\n<p><strong>Amsterdam II criteria<\/strong><\/p>\n<ol>\n<li>Three or more relatives with histologically verified Lynch syndrome\u2013associated cancer, one of whom is a first-degree relative of the other two*<\/li>\n<li>Cancer involving at least two generations<\/li>\n<li>One or more cancer cases diagnosed before 50 years of age<\/li>\n<\/ol>\n<p><strong>Revised Bethesda guidelines<\/strong><\/p>\n<ol>\n<li>Diagnosis of colorectal cancer or endometrial cancer in a patient younger than 50 years of age<\/li>\n<li>Presence of synchronous colorectal cancers, metachronous colorectal cancers, or other Lynch syndrome\u2013associated tumors, regardless of patient age<\/li>\n<li>Diagnosis of colorectal cancer with a high frequency of microsatellite instability on the basis of histologic findings (Crohn\u2019s-like lymphocytic reaction, mucinous or signet-ring cell differentiation, or medullary growth pattern) in a patient younger than 60 years of age<\/li>\n<li>Diagnosis of colorectal cancer in one or more first-degree relatives with a Lynch syndrome\u2013related tumor, with one of the diagnoses occurring before 50 years of age<\/li>\n<li>Diagnosis of colorectal cancer in two or more first- or second-degree relatives with Lynch syndrome\u2013related tumors, regardless of patient age<\/li>\n<\/ol>\n<p>* Lynch syndrome\u2013associated tumors include cancers of the colon and rectum, endometrium, stomach, ovary, pancreas, ureter, renal pelvis, biliary tract, brain, small bowel, and sebaceous glands, as well as keratoacanthomas.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>G\u00f3mez-Molina R, Mart\u00ednez R, Su\u00e1rez M, Pe\u00f1a-Cabia A, Calder\u00f3n MC, Mateo J. Lynch syndrome and colorectal cancer: A review of current perspectives in molecular genetics and clinical strategies. Oncol Res. 2025 Jun 26;33(7):1531-1545. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40612862\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Sinicrope FA. Lynch Syndrome-Associated Colorectal Cancer.\u00a0N Engl J Med. 2018 Aug 23;379(8):764-773. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30134129\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Stoffel EM, Mangu PB, Gruber SB, Hamilton SR, Kalady MF, Lau MW, Lu KH, Roach N, Limburg PJ; American Society of Clinical Oncology; European Society of Clinical Oncology. Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines.\u00a0J Clin Oncol. 2015 Jan 10;33(2):209-17\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25452455\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Mar 18, 2019.<br \/>\nUp-date Feb 4, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[272],"tags":[123,13,273,274,275,5,4],"class_list":["post-2162","post","type-post","status-publish","format-standard","hentry","category-oncology","tag-diagnosis","tag-diagnostico","tag-guia","tag-guidelines","tag-lynch","tag-sindrome","tag-syndrome"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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