{"id":2172,"date":"2018-12-03T20:28:04","date_gmt":"2018-12-03T20:28:04","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/?p=1389"},"modified":"2026-02-09T18:48:46","modified_gmt":"2026-02-09T18:48:46","slug":"ppis","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/ppis\/","title":{"rendered":"Approved Indications for Proton Pump Inhibitors (PPIs)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>First introduced in 1989, proton pump inhibitors (PPIs) are among the most widely utilized medications worldwide, both in the ambulatory and inpatient clinical settings. The PPIs are currently approved by the US Food and Drug Administration (FDA) for the management of a variety of gastrointestinal disorders including symptomatic peptic ulcer disease, gastroesophageal reflux disease, and nonulcer dyspepsia as well as for prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy.<!--more--><\/p>\n<p><strong>Food and Drug Administration Approved Indications for Proton Pump Inhibitors<\/strong><\/p>\n<figure id=\"attachment_1405\" aria-describedby=\"caption-attachment-1405\" style=\"width: 1833px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1405 size-full\" src=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2018\/11\/ppi.jpg\" alt=\"Food and Drug Administration Approved Indications for Proton Pump Inhibitors\" width=\"1833\" height=\"1477\" \/><figcaption id=\"caption-attachment-1405\" class=\"wp-caption-text\">Food and Drug Administration Approved Indications for Proton Pump Inhibitors<\/figcaption><\/figure>\n<p>NASID, nonsteroidal anti-inflammatory drugs; GI, gastrointestinal; IV, intravenous; NG, nasogastric.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Rossi A, Perrella L, Scotti S, Olmastroni E, Galimberti F, Ardoino I, Orlando V, Menditto E, Franchi C, Casula M. Approaches to Deprescribing Proton Pump Inhibitors in Clinical Practice: A Systematic Review. J Clin Med. 2024 Oct 21;13(20):6283. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39458232\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Strand DS, Kim D, Peura DA. 25 Years of Proton Pump Inhibitors: A Comprehensive Review.\u00a0Gut Liver. 2017 Jan 15;11(1):27-37. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27840364\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Nehra AK, Alexander JA, Loftus CG, Nehra V. Proton Pump Inhibitors: Review of Emerging Concerns.\u00a0Mayo Clin Proc. 2018 Feb;93(2):240-246.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29406201\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Nov 15, 2018.<br \/>\nUp-date Feb 9, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[53],"tags":[334,339,341,333,74,73,340,337,338,335,342,336],"class_list":["post-2172","post","type-post","status-publish","format-standard","hentry","category-gastroenterology","tag-approved","tag-aprobadas","tag-bomba","tag-ibp","tag-indicaciones","tag-indications","tag-inhibidores","tag-inhibitors","tag-ppis","tag-proton","tag-protones","tag-pump"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2172"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2172\/revisions"}],"predecessor-version":[{"id":10643,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2172\/revisions\/10643"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}