{"id":2307,"date":"2017-09-28T19:20:03","date_gmt":"2017-09-28T19:20:03","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/phararb\/"},"modified":"2025-05-13T20:25:29","modified_gmt":"2025-05-13T20:25:29","slug":"phararb","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/phararb\/","title":{"rendered":"Comparative Efficacy and Safety of the Angiotensin Receptor Blockers (ARBs)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<div>The appearance of angiotensin receptor blockers (ARBs) amongst the therapeutic options in the treatment of cardiovascular diseases (CVDs) was a new milestone in the history of hypertension treatment. It further widened the range of possibilities for personalized therapy, especially for patients who cannot tolerate the use of angiotensin converting enzyme inhibitors (ACEIs). <!--more--><\/div>\n<div><\/div>\n<div>\n<div><\/div>\n<div><b>Pharmacologic Characteristics of the Angiotensin Receptor Blockers<\/b><\/div>\n<div><span style=\"font-size: 12.16px;\">\u00a0<\/span><\/div>\n<div>\n<table class=\"MsoTableGrid\" style=\"border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-yfti-tbllook: 480; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-border-insideh: .5pt solid windowtext; mso-border-insidev: .5pt solid windowtext;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>ARBs<\/b><\/p>\n<\/td>\n<td style=\"border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>Half-life (h)\u00a0<\/b><\/p>\n<\/td>\n<td style=\"border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>Tmax (h)<\/b><\/p>\n<\/td>\n<td style=\"border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>Bio-availability<\/b><\/p>\n<\/td>\n<td style=\"border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>Route of elimination:<br \/>\n<\/b><b style=\"font-family: inherit; font-size: inherit;\">renal (R) biliary\/fecal (B)<\/b><b><br \/>\n<\/b><\/p>\n<\/td>\n<td style=\"border-top: 1pt solid windowtext; border-right: 1pt solid windowtext; border-bottom: 1pt solid windowtext; border-image: initial; border-left: none; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\"><b>Food Interaction<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Losartan*<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">2<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">1\u20131.5<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">33%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">35% R; 60% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0Yes<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Candesartan cilexetil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">9<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">2-5<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">42%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">33% R; 67% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0No<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Eprosartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">5\u20139<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">1\u20133<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">63%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">7% R; 90% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0Yes<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Irbesartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">11\u201315<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">1.3\u20133<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">60\u201380%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">20% R; 80% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0No<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Telmisartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">24<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">0.5\u20131<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">43%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">&lt;1% R; &gt;97% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0No<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Valsartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">6<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">2\u20134<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">23%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">13% R; 83% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0Yes<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Olmesartan medoxomil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">12\u201314<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">1.7\u20132.5<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">26%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">35\u201350%R; 50\u201365% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0No<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\">Azilsartan medoxomil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">12<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">1.5\u20133<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">60%<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">42% urine; 55% B<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: 1pt solid windowtext; border-right: 1pt solid windowtext; padding: 0cm 5.4pt; text-align: center;\" valign=\"top\">\n<p class=\"MsoNormal\">\u00a0No<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"MsoNormal\">*Losartan is converted to EXP-3174 with terminal half-life of 6\u20139 hours and Tmax of 4\u20136 hours.<\/p>\n<p class=\"MsoNormal\"><span style=\"font-size: 12.16px;\">\u00a0<\/span><\/p>\n<\/div>\n<div>\n<div><b>Doses for Hypertension and Other Indications of the Angiotensin Receptor Blockers<\/b><\/div>\n<div><span lang=\"ES-AR\" style=\"font-size: 12.16px;\">\u00a0<\/span><span style=\"font-size: 12.16px;\">\u00a0<\/span><\/div>\n<div>\n<table class=\"MsoTableGrid\" style=\"border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><b>ARBs<\/b><\/p>\n<\/td>\n<td style=\"border: solid windowtext 1.0pt; border-left: none; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><b>Starting dose (mg\/day)<\/b><\/p>\n<\/td>\n<td style=\"border: solid windowtext 1.0pt; border-left: none; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><b>Maximum dose (mg\/day)<\/b><\/p>\n<\/td>\n<td style=\"border: solid windowtext 1.0pt; border-left: none; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><b>Dosing interval<\/b><\/p>\n<\/td>\n<td style=\"border: solid windowtext 1.0pt; border-left: none; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><b>Other Indications Approved Outside of Hypertension<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Losartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">50<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0<\/span>100<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day or twice a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">Diabetic nephropathy when serum creatinine is increased and proteinuria present in patients with hypertension and type 2 diabetes; Stroke reduction in patients with hypertension and left ventricular hypertrophy (non-black only)<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Candesartan cilexetil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">16<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a032\u00a0<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">Once a day or twice a day\u00a0<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Treatment of heart failure (NYHA Classes II\u2013IV)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Eprosartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">600<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0800<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day or twice a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">None<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Irbesartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">150<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0<\/span>300<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">Diabetic nephropathy when serum creatinine is increased and proteinuria present in patients with hypertension and type 2 diabetes<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Telmisartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">40<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0<\/span>80<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">Once a day\u00a0<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Cardiovascular risk reduction in patients unable to take ACE inhibitors<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Valsartan<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">80 or 160<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0<\/span>320<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">Treatment of heart failure (NYHA Classes II\u2013IV); Reduction of CV mortality in clinically stable patients with left ventricular failure or dysfunction following myocardial infarction.<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Olmesartan medoxomil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">20<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a0<\/span>40<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">None<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"border: solid windowtext 1.0pt; border-top: none; mso-border-top-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Azilsartan medoxomil<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">40 or 80<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\"><span lang=\"ES-AR\">\u00a080<\/span><\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">Once a day<\/p>\n<\/td>\n<td style=\"border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; mso-border-left-alt: solid windowtext .5pt; mso-border-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt;\" valign=\"top\">\n<p class=\"MsoNormal\" style=\"margin-bottom: .0001pt; line-height: normal;\">None<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>&nbsp;<\/p>\n<div><\/div>\n<\/div>\n<\/div>\n<div><\/div>\n<div><b>References:<\/b><\/div>\n<div>\n<ol>\n<li>Abraham HM, White CM, White WB. The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases.\u00a0Drug Saf. 2015 Jan;38(1):33-54. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25416320\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Makani H, Bangalore S, Supariwala A, Romero J, Argulian E, Messerli FH. Antihypertensive efficacy of angiotensin receptor blockers as monotherapy as evaluated by ambulatory blood pressure monitoring: a meta-analysis.\u00a0Eur Heart J. 2014 Jul;35(26):1732-42. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23966312\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>D\u00e9zsi CA. The Different Therapeutic Choices with ARBs. Which One to Give? When? Why? Am J Cardiovasc Drugs. 2016 Aug;16(4):255-66. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26940560\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<\/div>\n<div><\/div>\n<div>Created Sep 28, 2017.<\/div>\n<div><\/div>\n<p><\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[594],"tags":[608,607,606,605,604,603,602,601,600,561,562,599,564,598,597,596,595,609],"class_list":["post-2307","post","type-post","status-publish","format-standard","hentry","category-pharmacology","tag-acei","tag-aceis","tag-angiotensin","tag-angiotensina","tag-antagonistas","tag-ara","tag-arb","tag-arbs","tag-blockers","tag-comparativa","tag-comparative","tag-efficacy","tag-eficacia","tag-ieca","tag-receptor","tag-receptores","tag-safety","tag-seguridad"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2307"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2307\/revisions"}],"predecessor-version":[{"id":8738,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2307\/revisions\/8738"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}