{"id":2316,"date":"2017-01-26T12:19:43","date_gmt":"2017-01-26T12:19:43","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/diablada\/"},"modified":"2026-03-10T20:01:08","modified_gmt":"2026-03-10T20:01:08","slug":"diablada","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/diablada\/","title":{"rendered":"Diagnostic Criteria of Latent Autoimmune Diabetes in Adults (LADA)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Latent autoimmune diabetes in adults (LADA) accounts for 2%-12% of all cases of diabetes. Patients are typically diagnosed after 35 years of age and are often misdiagnosed as type II Diabetes Mellitus (DM). Glycemic control is initially achieved with sulfonylureas, but patients eventually become insulin dependent more rapidly than with type II DM patients.<br \/>\n<!--more--><br \/>\n<b>Diagnostic Criteria of Latent Autoimmune Diabetes in Adults (LADA)<\/b><br \/>\nTo discriminates LADA from type I and\/or type II\u00a0DM, diagnosis of LADA has been based on three criteria\u00a0as given by The Immunology of Diabetes Society:<\/p>\n<ol>\n<li>Adult age of onset (&gt; 30 years of age);<\/li>\n<li>Presence of at least one circulating autoantibodies (GADA\/ICA\/IAA\/IA-2); and<\/li>\n<li>Initial insulin independence (for the first six months).<\/li>\n<\/ol>\n<p>In a retrospective study by Fourlanos\u00a0et al, five clinical parameters were found to be more\u00a0frequent in LADA than in type II DM:<\/p>\n<ol>\n<li>Age of onset &lt; 50 years;<\/li>\n<li>Acute symptoms (polyuria\/polydypsia\/weight loss);<\/li>\n<li>BMI &lt; 25 kg\/m2<\/li>\n<li>Personal history of other autoimmune diseases; and<\/li>\n<li>Family history of autoimmune disease.<\/li>\n<\/ol>\n<p>Other workers have also\u00a0reported a lower BMI, waist\/hip ratio, total cholesterol and triglycerides\u00a0levels and higher HDL-CH in LADA than in patients\u00a0with type II DM. The prevalence of hypertension was\u00a0also lower in LADA patients.<br \/>\nAbbreviations:<\/p>\n<ul>\n<li>LADA: Latent Autoimmune Diabetes in Adults;<\/li>\n<li>GADA: Anti Glutamic Acid Decarboxylase Antibodies;<\/li>\n<li>ICA: islet cell antibody;<\/li>\n<li>IAA: insulin autoantibody;<\/li>\n<li>IA2: antibodies: AntiTyrosine Phosphatase IA2 Antibodies;<\/li>\n<li>BMI: Body Mass Index;<\/li>\n<li>HLA: Human Leukocyte Antigen<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><b>References:<\/b><\/p>\n<ol>\n<li>Nambam B, Aggarwal S, Jain A. Latent autoimmune diabetes in adults: A distinct but heterogeneous clinical entity.\u00a0World J Diabetes. 2010 Sep 15;1(4):111-5.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21537436\/\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0[Medline]<\/a><\/li>\n<li>Laugesen E, \u00d8stergaard JA, Leslie RD; Danish Diabetes Academy Workshop and Workshop Speakers. Latent autoimmune diabetes of the adult: current knowledge and uncertainty. Diabet Med. 2015 Jul;32(7):843-52.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25601320\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Liao Y, Xiang Y, Zhou Z. Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection.\u00a0Front Med. 2012 Sep;6(3):243-7.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22843304\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Fourlanos S, Perry C, Stein MS, Stankovich J, Harrison LC, Colman PG. A clinical screening tool identifies autoimmune diabetes in adults. Diabetes Care. 2006 May;29(5):970-5.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16644622\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Ravikumar V, Ahmed A, Anjankar A. A Review on Latent Autoimmune Diabetes in Adults. Cureus. 2023 Oct 29;15(10):e47915. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38034250\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Jan 25, 2017.<br \/>\nUp-date Mar 10, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[626],"tags":[657,656,250,251,16,15,211,14,13,655,654,658],"class_list":["post-2316","post","type-post","status-publish","format-standard","hentry","category-diabetes","tag-adultos","tag-adults","tag-autoimmune","tag-autoinmune","tag-criteria","tag-criterios","tag-diabetes","tag-diagnostic","tag-diagnostico","tag-lada","tag-latent","tag-latente"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2316"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2316\/revisions"}],"predecessor-version":[{"id":10696,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2316\/revisions\/10696"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}