{"id":2319,"date":"2016-12-29T15:02:08","date_gmt":"2016-12-29T15:02:08","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/infcd\/"},"modified":"2026-03-12T19:45:48","modified_gmt":"2026-03-12T19:45:48","slug":"infcd","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/infcd\/","title":{"rendered":"Definitions of Clostridium difficile Infection (CDI)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Clostridium difficile (C. difficile) is a Gram-positive, sporeforming bacterium usually spread by the fecal-oral route. It is non-invasive and produces toxins A and B that cause disease, ranging from asymptomatic carriage, to mild diarrhea, to colitis, or pseudomembranous colitis. CDI is defined as the acute onset of diarrhea with documented toxigenic C. difficile or its toxin and no other documented cause for diarrhea.<br \/>\n<!--more--><\/p>\n<p><b>Definitions of Clostridium difficile Infection (CDI)<\/b><br \/>\nUse of standardized definitions for CDI (health-care onset-health-care\u00a0facility associated (HO-HCFA), community onset-health-care facility\u00a0associated (CO-HCFA), community associated (CA), or indeterminate\u00a0disease (ID) will allow comparison among studies.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr valign=\"TOP\">\n<td width=\"197\"><b>Type of case<\/b><\/td>\n<td width=\"271\"><b>Definition<\/b><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"197\">Health-care facility-onset\u00a0health-care facility\u00a0associated (HO-HCFA)<\/td>\n<td width=\"271\">Occurs when onset of symptoms 3 days\u00a0after admission to a health-care facility.<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"197\">Community onset healthcare\u00a0facility associated\u00a0(CO-HCFA)<\/td>\n<td width=\"271\">Onset of symptoms within 4 weeks after\u00a0being discharged from a health-care\u00a0facility.<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"197\">Community associated (CA)<\/td>\n<td width=\"271\">Occurs when onset of symptoms occurs\u00a0outside a health-care facility or &lt; 3 days\u00a0after admission to a health-care facility and\u00a0has not been discharged from a healthcare\u00a0facility in the previous 12 weeks.<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"197\">Indeterminate or unknown\u00a0onset (ID)<\/td>\n<td width=\"271\">CDI develops after being discharged from a\u00a0health-care facility 4 \u2013 12 weeks previously.<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"197\">Recurrent CDI<\/td>\n<td width=\"271\">Episode of CDI that occurs 8 weeks after\u00a0the onset of a previous episode, provided\u00a0the symptoms from the previous episode\u00a0resolved.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><b>References:<\/b><\/p>\n<ol>\n<li>Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, McFarland LV, Mellow M, Zuckerbraun BS. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections.\u00a0Am J Gastroenterol. 2013 Apr;108(4):478-98.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23439232\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults: a systematic review.\u00a0JAMA. 2015 Jan 27;313(4):398-408.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25626036\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Kelly CR, Allegretti JR. Review Article: Gastroenterology and Clostridium difficile Infection: Past, Present, and Future. Clin Infect Dis. 2023 Dec 5;77(Suppl 6):S463-S470. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38051967\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Jan 05, 2017.<br \/>\nUp-date Mar 12. 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[39],"tags":[666,665,314,353,313,352,664,266,267],"class_list":["post-2319","post","type-post","status-publish","format-standard","hentry","category-infetious-disease","tag-cdi","tag-clostridium","tag-definicion","tag-definiciones","tag-definition","tag-definitions","tag-difficile","tag-infeccion","tag-infection"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2319","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2319"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2319\/revisions"}],"predecessor-version":[{"id":10697,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2319\/revisions\/10697"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2319"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2319"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}