{"id":2344,"date":"2015-06-22T13:51:40","date_gmt":"2015-06-22T13:51:40","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/reufmf\/"},"modified":"2026-03-25T19:12:18","modified_gmt":"2026-03-25T19:12:18","slug":"reufmf","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/reufmf\/","title":{"rendered":"Diagnostic Criteria of Familial Mediterranean Fever (FMF)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The diagnosis of familial Mediterranean fever (FMF) is based upon three factors: typical clinical manifestations, a positive response to colchicine therapy, and genetic testing, although currently available tests do not detect all mutations associated with FMF.<br \/>\n<!--more--><br \/>\n<b>Diagnostic Criteria of Familial Mediterranean Fever (FMF)<\/b><br \/>\n<b><\/b><\/p>\n<p><b>Tel-Hashomer criteria:<\/b><br \/>\n<b><\/b><\/p>\n<p><b>Major criteria<\/b><\/p>\n<ul>\n<li>Recurrent febrile episodes associated with peritonitis, pleuritis or synovitis<\/li>\n<li>Amyloidosis of AA-type without a predisposing disease<\/li>\n<li>Favorable response to daily colchicine<\/li>\n<\/ul>\n<p><b>Minor criteria<\/b><\/p>\n<ul>\n<li>Recurrent febrile episodes<\/li>\n<li>Erysipelas-like erythema<\/li>\n<li>Positive history of familial Mediterranean fever in a first degree relative<\/li>\n<\/ul>\n<p><b>Definite\u00a0<\/b><b>Diagnosis:<\/b>\u00a02 major or 1 major + 2 minor criteria.<br \/>\n<b>Probable D<\/b><b>iagnosis:<\/b>\u00a01 major + 1 minor criteria.<br \/>\n<b><\/b><\/p>\n<p><b>Livneh criteria<\/b><br \/>\n<b><\/b><\/p>\n<p><b>Major criteria:<\/b><br \/>\nTypical attacks of:<\/p>\n<ul>\n<li>Peritonitis (generalized)<\/li>\n<li>Pleuritis (unilateral) or pericarditis<\/li>\n<li>Monoarthritis (hip, knee, or ankle)<\/li>\n<li>Fever alone<\/li>\n<\/ul>\n<p>Incomplete abdominal attacks<br \/>\n<b><\/b><\/p>\n<p><b>Minor criteria<\/b><br \/>\n1-2 Incomplete attacks affecting one or more sites<\/p>\n<ul>\n<li>Abdomen<\/li>\n<li>Chest<\/li>\n<li>Joint<\/li>\n<li>Exertional leg pain<\/li>\n<li>Response to colchicine<\/li>\n<\/ul>\n<p><b>Definitive diagnosis:\u00a0<\/b>1 major criterion or 2 minor criteria.<br \/>\n<b><\/b><\/p>\n<p><b>Typical attacks<\/b>\u00a0are defined as recurrent (&gt;\/=3 of the same type), febrile (rectal temperature of 38\u00b0C (100\u00b0F) or higher), and short (lasting between 12 hours and 3 days).<br \/>\n<b><\/b><\/p>\n<p><b>Incomplete attacks<\/b>\u00a0are defined as painful and recurrent, differing from typical attacks in 1 or 2 features, as follows:<\/p>\n<ol>\n<li>The temperature is normal or lower than 38\u00b0C (100\u00b0F)<\/li>\n<li>The attacks are longer or shorter than specified (but no shorter than 6 hours or longer than a week)<\/li>\n<li>No signs of peritonitis are recorded during the abdominal attacks<\/li>\n<li>The abdominal attacks are localized<\/li>\n<li>The arthritis is in joints other than those specified.<\/li>\n<\/ol>\n<p><b>Turkish Pediatric Criteria<\/b><\/p>\n<ol>\n<li>\u00a0Fever: axillary temperature &gt;38 \u00b0C, duration 6\u201372 h and &gt;\/=3 attacks<\/li>\n<li>\u00a0Abdominal pain: duration 6\u201372 h and &gt;\/=3 attacks<\/li>\n<li>\u00a0Chest pain: duration 6\u201372 h and\u00a0&gt;\/=3 attacks<\/li>\n<li>\u00a0Arthritis: duration 6\u201372 h,\u00a0&gt;\/=3 attacks, and oligoarthritis<\/li>\n<li>\u00a0Family history of FMF<\/li>\n<\/ol>\n<p><b>Definitive diagnosis:\u00a0<\/b>The presence of at least 2 out of 5 criteria.<\/p>\n<p>&nbsp;<\/p>\n<p><b>References:<\/b><\/p>\n<ol>\n<li>Yal\u00e7inkaya F, Ozen S, Oz\u00e7akar ZB, Aktay N, Cakar N, D\u00fczova A, Kasap\u00e7opur O, Elhan AH, Doganay B, Ekim M, Kara N, Uncu N, Bakkaloglu A. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood.\u00a0Rheumatology (Oxford). 2009 Apr;48(4):395-8.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19193696\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Berkun Y, Eisenstein EM. Diagnostic criteria of familial Mediterranean fever. Autoimmun Rev. 2014 Apr-May;13(4-5):388-90.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24424166\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Giancane G, Ter Haar NM, Wulffraat N, Vastert SJ, Barron K, Hentgen V, Kallinich T, Ozdogan H, Anton J, Brogan P, Cantarini L, Frenkel J, Galeotti C, Gattorno M, Grateau G, Hofer M, Kone-Paut I, Kuemmerle-Deschner J, Lachmann HJ, Simon A, Demirkaya E, Feldman B, Uziel Y, Ozen S.\u00a0Evidence-based recommendations for genetic diagnosis of familial Mediterranean fever. Ann Rheum Dis. 2015 Apr;74(4):635-41.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25628446\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Ozen S, Sa\u011f E, Oton T, G\u00fcl A, Sieiro Santos C, Bayraktar D, Proft FN, Lachmann HJ, Kuemmerle Deschner J, Gattorno M, Ayaz NA, Karada\u011f \u00d6, Y\u00fcce S, Kivity S, Georgin-Lavialle S, Sarkisian T, Kallinich T, Hentgen V, Prior Y, Uziel Y, Yardeni Z, Carmona L. EULAR\/PReS endorsed recommendations for the management of familial Mediterranean fever (FMF): 2024 update. Ann Rheum Dis. 2025 Jun;84(6):899-909. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40234174\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Jun 22, 2015.<br \/>\nUp-date Mar 25, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45],"tags":[16,15,14,13,804,803,802,801,800,799,805],"class_list":["post-2344","post","type-post","status-publish","format-standard","hentry","category-rheumatology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-familial","tag-familiar","tag-fever","tag-fiebre","tag-fmf","tag-mediterranean","tag-mediterraneo"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2344","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2344"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2344\/revisions"}],"predecessor-version":[{"id":10727,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2344\/revisions\/10727"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2344"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2344"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2344"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}