{"id":2347,"date":"2015-03-11T12:41:25","date_gmt":"2015-03-11T12:41:25","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/onctm\/"},"modified":"2026-03-27T20:49:41","modified_gmt":"2026-03-27T20:49:41","slug":"onctm","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/onctm\/","title":{"rendered":"Tumor Markers in Clinical Practice"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Tumor markers are playing an increasingly important role in\u00a0cancer detection and management. These laboratory-based\u00a0tests are potentially useful in screening for early malignancy,\u00a0aiding cancer diagnosis, determining prognosis, surveillance\u00a0following curative surgery for cancer, up front predicting\u00a0drug response or resistance, and monitoring therapy in advanced\u00a0disease.<br \/>\n<!--more--><br \/>\n<strong>Tumor Markers in Clinical Practice<\/strong><br \/>\nBiomarkers that have undergone or are currently undergoing\u00a0evaluation in screening asymptomatic subjects for cancer<\/p>\n<ul>\n<li>Colorectal:\u00a0FOBT (Fecal Occult Blood Testing)<\/li>\n<li>Prostate:\u00a0PSA (Prostate-Specific Antigen)<\/li>\n<li>Ovarian:\u00a0CA 125 (Carbohydrate Antigen 125)<\/li>\n<li>Neuroblastoma:\u00a0VMA\/HVA (Vanillylmandelic acid\/homovanillic acid)<\/li>\n<li>Hepatocellular:\u00a0AFP (alpha-fetoprotein)<\/li>\n<li>Gastric:\u00a0Pepsinogen<\/li>\n<li>Trophoblastic:\u00a0HCG (Human Chorionic Gonadotrophin)<\/li>\n<\/ul>\n<p>Markers that may be used for determining prognosis in different cancers<\/p>\n<ul>\n<li>Breast: Oncotype DX, uPA\/PAI-1 (urokinase-type plasminogen activator \/ human plasminogen activator inhibitor type 1)<\/li>\n<li>Germ cell: AFP, HCG, LDH (Lactate dehydrogenase)<\/li>\n<li>Colorectal: CEA (carcinoembryonic antigen), MSI (microsatellite instability)<\/li>\n<li>Prostate: PSA<\/li>\n<li>Ovarian: CA 125<\/li>\n<\/ul>\n<p>Serum markers that may be used in postoperative surveillance\u00a0and monitoring therapy in different cancers<\/p>\n<ul>\n<li>Colorectal: CEA<\/li>\n<li>Hepatocellular: AFP<\/li>\n<li>Pancreatic: CA 19-9<\/li>\n<li>Ovarian: CA 125<\/li>\n<li>Breast: CA 15-3<\/li>\n<li>Prostate: PSA<\/li>\n<li>Germ cell: AFP, HCG<\/li>\n<li>Lung (non-small cell): Serum Fragment of Cytokeratin Subunit 19 measured by CYFRA 21-1, squamous cell carcinoma (SCC) antigen<\/li>\n<li>Lung (small cell): NSE (neuron-specific enolase), Progastrin-releasing peptide (ProGRP)<\/li>\n<li>Melanoma: S100<\/li>\n<li>Trophoblastic: HCG<\/li>\n<li>Thyroid (differentiated): thyroglobulin<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Duffy MJ. Tumor markers in clinical practice: a review focusing on common solid cancers.\u00a0Med Princ Pract. 2013;22(1):4-11.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22584792\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Duffy MJ. Role of tumor markers in patients with solid cancers: A critical review.\u00a0Eur J Intern Med. 2007 May;18(3):175-84.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17449388\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Sundaresan S, Rajapriya P, Lavanya SK. Aging and cancer: Clinical role of tumor markers in the geriatric population (Review). Med Int (Lond). 2024 Mar 6;4(3):21. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39640494\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Mar 11, 2015.<br \/>\nUp-date: Mar 27, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[272],"tags":[812,813,323,814,815,816,817],"class_list":["post-2347","post","type-post","status-publish","format-standard","hentry","category-oncology","tag-clinica","tag-marcadores-clinical","tag-markers","tag-practica","tag-practice","tag-tumor","tag-tumorales"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2347"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2347\/revisions"}],"predecessor-version":[{"id":10728,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2347\/revisions\/10728"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2347"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2347"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}