{"id":2355,"date":"2014-11-06T15:43:12","date_gmt":"2014-11-06T15:43:12","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/hemth\/"},"modified":"2025-05-13T20:27:00","modified_gmt":"2025-05-13T20:27:00","slug":"hemth","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/hemth\/","title":{"rendered":"Features of the Thalassemias"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The thalassemias are a group of inherited hematologic disorders caused by defects in the synthesis of one or more of the hemoglobin chains. Alpha thalassemia is caused by reduced or absent synthesis of alpha globin chains, and beta thalassemia is caused by reduced or absent synthesis of beta globin chains. Imbalances of globin chains cause hemolysis and impair erythropoiesis.<br \/>\n<!--more--><br \/>\n<b>Hematologic Indices of Iron Deficiency and Alpha and Beta Thalassemia<\/b><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr valign=\"TOP\">\n<td width=\"200\"><b>Test<\/b><\/td>\n<td style=\"text-align: center;\" width=\"120\"><b>Iron Deficiency<\/b><\/td>\n<td style=\"text-align: center;\" width=\"120\"><b>Beta Thalassemia<\/b><\/td>\n<td style=\"text-align: center;\" width=\"120\"><b>Alpha Thalassemia<\/b><\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"200\">MCV (abnormal if &lt; 80 fl in adults; &lt; 70 fl in children six months to six years of age; and &lt; 76 fl in children seven to 12 years of age)<\/td>\n<td style=\"text-align: center;\" width=\"120\">Low<\/td>\n<td style=\"text-align: center;\" width=\"120\">Low<\/td>\n<td style=\"text-align: center;\" width=\"120\">Low<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"200\">Red blood cell distribution width<\/td>\n<td style=\"text-align: center;\" width=\"120\">High<\/td>\n<td style=\"text-align: center;\" width=\"120\">Normal; occasionally high<\/td>\n<td style=\"text-align: center;\" width=\"120\">Normal<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"200\">Ferritin<\/td>\n<td style=\"text-align: center;\" width=\"120\">Low<\/td>\n<td style=\"text-align: center;\" width=\"120\">Normal<\/td>\n<td style=\"text-align: center;\" width=\"120\">Normal<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"200\">Mentzer index for children (MCV\/red blood cell count)<\/td>\n<td style=\"text-align: center;\" width=\"120\">&gt; 13<\/td>\n<td style=\"text-align: center;\" width=\"120\">&lt; 13<\/td>\n<td style=\"text-align: center;\" width=\"120\">&lt; 13<\/td>\n<\/tr>\n<tr valign=\"TOP\">\n<td width=\"200\">Hb electrophoresis<\/td>\n<td style=\"text-align: center;\" width=\"120\">Normal (may have reduced HbA2)<\/td>\n<td style=\"text-align: center;\" width=\"120\">Increased HbA2, reduced HbA, and probably increased HbF<\/td>\n<td style=\"text-align: center;\" width=\"120\">Adults: normal Newborns: may have HbH or Hb Bart&#8217;s<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Hb = hemoglobin; HbF = fetal hemoglobin; MCV = mean corpuscular volume.<\/p>\n<p>&nbsp;<\/p>\n<p><b>References:<\/b><\/p>\n<ol>\n<li>Martin A, Thompson AA. Thalassemias. Pediatr Clin North Am. 2013 Dec;60(6):1383-91.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24237977\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Muncie HL Jr, Campbell J. Alpha and beta thalassemia. Am Fam Physician. 2009 Aug 15;80(4):339-44.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19678601\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Sep 14, 2015<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[864,863,862,861,860,41,859,858,857,856,855,865],"class_list":["post-2355","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-alfa","tag-alpha","tag-beta","tag-cadenas","tag-chains","tag-features","tag-hemoglobin","tag-hemoglobina","tag-talasemia","tag-talasemias","tag-thalassemia","tag-thalassemias"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - 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