{"id":2357,"date":"2014-11-03T15:56:01","date_gmt":"2014-11-03T15:56:01","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/5mdd\/"},"modified":"2026-04-08T19:55:43","modified_gmt":"2026-04-08T19:55:43","slug":"5mdd","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/5mdd\/","title":{"rendered":"DSM-5 Diagnostic Criteria for Major Depressive Disorder"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>The diagnostic criteria for major depression in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), require the presence of either sadness\u00a0<span style=\"line-height: 1.3em;\">or anhedonia with a total of five or more symptoms over a 2-week period. <\/span><br \/>\n<!--more--><br \/>\n<script async src=\"\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script><br \/>\n<ins class=\"adsbygoogle\" style=\"display: block; text-align: center;\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\" data-ad-client=\"ca-pub-0127150553352455\" data-ad-slot=\"7834404329\"><\/ins><br \/>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script><br \/>\n<strong style=\"line-height: 1.3em;\">DSM-5 Diagnostic Criteria for Major Depressive\u00a0<span style=\"line-height: 1.3em;\">Disorder<\/span><\/strong><br \/>\nFive or more of the following symptoms must be present\u00a0<span style=\"line-height: 1.3em;\">nearly every day during a 2-wk period:<\/span><br \/>\nCore symptoms (&gt;\/= 1 required for diagnosis)<\/p>\n<ul>\n<li><span style=\"line-height: 1.3em;\">Depressed mood most of the day<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Anhedonia or markedly decreased interest or pleasure <\/span><span style=\"line-height: 1.3em;\">in almost all activities<\/span><\/li>\n<\/ul>\n<p>Additional symptoms<\/p>\n<ul>\n<li><span style=\"line-height: 1.3em;\">Clinically significant weight loss or increase or decrease <\/span><span style=\"line-height: 1.3em;\">in appetite<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Insomnia or hypersomnia<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Psychomotor agitation or retardation<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Fatigue or loss of energy<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Feelings of worthlessness or excessive or inappropriate <\/span><span style=\"line-height: 1.3em;\">guilt<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Diminished ability to think or concentrate, or indecisiveness<\/span><\/li>\n<li><span style=\"line-height: 1.3em;\">Recurrent thoughts of death or suicidal ideation<\/span><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medicalcriteria.com\/web\/hamilton-depression-scale\/\" target=\"_blank\" rel=\"noopener noreferrer\">Hamilton Depression Rating Scale (HAM-D)<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li><span style=\"line-height: 1.3em;\">Taylor WD. Clinical practice. Depression in the elderly. N Engl J Med. 2014 Sep 25;371(13):1228-36. <\/span><a style=\"line-height: 1.3em;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25251617\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li><span style=\"line-height: 1.3em;\">Diagnostic and statistical manual of mental disorders, 5th ed. rev.: DSM-V. Washington, DC: American Psychiatric Association, 2013.<\/span><\/li>\n<li>Liloia D, Rocca P, Brasso C, Tanaka M, Manuello J, Crocetta A, Duca S, Costa T, Cauda F. Identification of a diagnosis-selective neurobiological substrate for bipolar disorder, major depressive disorder, and schizophrenia: a meta-analysis of 57,717 subjects. Psychol Med. 2026 Feb 24;56:e52. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41731301\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>This material was taken from the DSM-5. It is intended for educational purposes only.<\/p>\n<p>&nbsp;<\/p>\n<p>Created Nov 03, 2014.<br \/>\nUp-date Apr 08, 2026.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[76],"tags":[832,16,15,878,877,14,13,85,534,84,876,879],"class_list":["post-2357","post","type-post","status-publish","format-standard","hentry","category-psychiatry","tag-832","tag-criteria","tag-criterios","tag-depresion","tag-depressive","tag-diagnostic","tag-diagnostico","tag-disorder","tag-dsm","tag-dsm-5","tag-major","tag-mayor"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2357"}],"version-history":[{"count":9,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2357\/revisions"}],"predecessor-version":[{"id":10736,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2357\/revisions\/10736"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}