{"id":2389,"date":"2012-12-27T12:09:11","date_gmt":"2012-12-27T12:09:11","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/retinopathy-of-prematurity\/"},"modified":"2025-05-13T20:28:17","modified_gmt":"2025-05-13T20:28:17","slug":"retinopathy-of-prematurity","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/retinopathy-of-prematurity\/","title":{"rendered":"Classification of Retinopathy of Prematurity (RP)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Retinopathy of prematurity is a vision-threatening disease associated with abnormal retinal vascular development that occurs only in premature infants.<br \/>\n<!--more--><br \/>\n<strong>Criteria for screening<\/strong><\/p>\n<ul>\n<li>United States: infants with a gestational age of ?30 weeks or birth weight of &lt;1500 g and selected infants with a gestational age of &gt;30 weeks and an unstable clinical course<\/li>\n<li>United Kingdom: infants with a gestational age of &lt;\/=31 weeks or birth weight of &lt;\/=1500 g<\/li>\n<li>Canada: infants with a gestational age of &lt;\/=30 weeks, 6 days, or birth weight of &lt;\/=1250 g<\/li>\n<\/ul>\n<p><strong>Timing of screening and examinations<\/strong><\/p>\n<ul>\n<li>First examination at chronologic age of 4\u20136 weeks or postgestational age of 31 weeks<\/li>\n<li>Repeated examinations recommended by examining ophthalmologist on the basis of retinal findings and suggested schedule<\/li>\n<\/ul>\n<p><strong>Type of examination<\/strong><\/p>\n<ul>\n<li>Dilated binocular indirect ophthalmoscopy<\/li>\n<li>Ongoing studies of validation and reliability of retinal imaging as a potential telemedicine alternative for screening by indirect ophthalmoscopy<\/li>\n<\/ul>\n<p><strong>Classification of retinopathy of prematurity determined in examinations<\/strong><br \/>\nZone (area of retinal vascularization)<\/p>\n<p style=\"padding-left: 30px;\">I: vascularization within a circle centered on the optic nerve, the radius of which is twice the distance from the optic nerve to the macula<br \/>\nII: vascularization extending beyond zone I, within a circle the radius of which is the distance from the optic nerve to the nasal ora serrata<br \/>\nIII: vascularization extending beyond zones I and II<\/p>\n<p>Stage (disease severity)<\/p>\n<p style=\"padding-left: 30px;\">1: line<br \/>\n2: ridge (with volume)<br \/>\n3: intravitreal angiogenesis<br \/>\n4: partial retinal detachment<br \/>\n5: total retinal detachment<br \/>\nPlus disease: dilatation and tortuosity of retinal vessels<\/p>\n<p><strong>Treatment<\/strong><br \/>\nApplication of laser to peripheral avascular retina for type 1 retinopathy of prematurity<\/p>\n<p style=\"padding-left: 30px;\">Zone I: stage 3, or stage 1 or 2 with plus disease<br \/>\nZone II: stage 2 or 3 with plus disease<\/p>\n<p>Under consideration, anti-VEGF agents for stage 3 and plus disease in zone I; additional study needed to determine dose, safety, and type of anti-VEGF therapy*<\/p>\n<p><strong>Visual rehabilitation<\/strong><br \/>\nCorrection often needed for associated refractive errors (ametropia and anisometropia); ongoing screening and treatment recommended for commonly associated amblyopia or strabismus; protective eyewear and low-vision aids may be indicated<br \/>\n* VEGF denotes vascular endothelial growth factor.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Hartnett ME, Penn JS. Mechanisms and Management of Retinopathy of Prematurity. N Engl J Med 2012;367(26):2515-2526 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23268666\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Quiram PA, Capone A Jr. Current understanding and management of retinopathy of prematurity. Curr Opin Ophthalmol. 2007 May;18(3):228-34. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17435431\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Dic 27, 2012.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[441],"tags":[166,167,1058,1059,1060,1061],"class_list":["post-2389","post","type-post","status-publish","format-standard","hentry","category-pediatrics","tag-clasificacion","tag-classification","tag-prematurity","tag-prematuro","tag-retinopathy","tag-retinopatia"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2389"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2389\/revisions"}],"predecessor-version":[{"id":9312,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2389\/revisions\/9312"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}