{"id":2407,"date":"2011-11-30T12:05:49","date_gmt":"2011-11-30T12:05:49","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/gashav\/"},"modified":"2025-05-13T20:28:28","modified_gmt":"2025-05-13T20:28:28","slug":"gashav","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/gashav\/","title":{"rendered":"Typical Serologic Course of Hepatitis A Virus (HAV) Infection"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Since both clinically and biochemically, acute hepatitis due to HAV cannot be distinguished from that due to the other hepatitis viruses, serologic tests are necessary for a virus-specific diagnosis.<br \/>\n<!--more--><br \/>\nDiagnosis of hepatitis is made by biochemical assessment of liver function (laboratory evaluation of: urine bilirubin and urobilinogen, total and direct serum bilirubin, ALT (SGPT) and\/or AST (SGOT), alkaline phosphatase, prothrombin time, total protein, albumin, IgG, IgA, IgM, complete blood count).<br \/>\nThe specific routine diagnosis of acute hepatitis A is made by finding anti-HAV IgM in the serum of patients. A second option is the detection of virus and\/or antigen in the faeces.<br \/>\nVirus and antibody can be detected by commercially available radioimmunoassay (RIA), enzyme immunoassay (EIA) and enzyme-linked immunosorbent assay (ELISA) kits. These commercially available assays for anti-HAV IgM and total anti-HAV (IgM and IgG) for assessment of immunity to HAV are not influenced by the passive administration of immunoglobulin (IG), because the prophylactic doses are below detection level.<br \/>\nAt the onset of disease, the presence of IgG anti-HAV is always accompanied by the presence of IgM anti-HAV. As IgG anti-HAV persists lifelong after acute infection, detection of IgG anti-HAV alone indicates past infection.<br \/>\nVirus may still be present in the absence of detectable HAV antigen, as demonstrated by the use of more sensitive methods.<\/p>\n<figure id=\"attachment_6703\" aria-describedby=\"caption-attachment-6703\" style=\"width: 1001px\" class=\"wp-caption alignnone\"><a href=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-6703 size-full\" src=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa.jpg\" alt=\"Typical Serologic Course of Hepatitis A Virus (HAV) Infection\" width=\"1001\" height=\"535\" srcset=\"https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa.jpg 1001w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa-300x160.jpg 300w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa-768x410.jpg 768w, https:\/\/medicalcriteria.com\/web\/wp-content\/uploads\/2019\/12\/hepatitisa-500x267.jpg 500w\" sizes=\"auto, (max-width: 1001px) 100vw, 1001px\" \/><\/a><figcaption id=\"caption-attachment-6703\" class=\"wp-caption-text\">Typical Serologic Course of Hepatitis A Virus (HAV) Infection<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Nainan OV, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006 Jan;19(1):63-79. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16418523\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Regev A, Schiff ER. Viral hepatitis A, B, and C. Clin Liver Dis. 2000 Feb;4(1):47-71. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11232191\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Advisory Committee on Immunization Practices (ACIP), Fiore AE, Wasley A, Bell BP. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2006 May 19;55(RR-7):1-23. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16708058\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created Dec 01, 2011.<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[53],"tags":[1148,1147,1146,1145,1144,266,267,1143,1142,1141,1140,716],"class_list":["post-2407","post","type-post","status-publish","format-standard","hentry","category-gastroenterology","tag-a","tag-course","tag-curso","tag-hav","tag-hepatitis","tag-infeccion","tag-infection","tag-serologic","tag-serologico","tag-tipico","tag-typical","tag-virus"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2407"}],"version-history":[{"count":5,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2407\/revisions"}],"predecessor-version":[{"id":8837,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2407\/revisions\/8837"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}