{"id":2468,"date":"2009-09-15T12:54:40","date_gmt":"2009-09-15T12:54:40","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/neurosfn\/"},"modified":"2025-05-14T19:09:00","modified_gmt":"2025-05-14T19:09:00","slug":"neurosfn","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/neurosfn\/","title":{"rendered":"Diagnostic Criteria for Small Fibre Neuropathy (SFN)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Small fiber neuropathy manifests in a variety of different diseases and often results in symptoms of burning pain, shooting pain, allodynia, and hyperesthesia.<\/p>\n<p><!--more--><\/p>\n<p>Patients are diagnosed with small fibre neuropathy (SFN) when at least two of the following examinations are abnormal:<\/p>\n<ol>\n<li>Clinical signs of small fibre impairment (pinprick and thermal sensory loss and\/or allodynia and\/or hyperalgesia), which distribution is consistent with peripheral neuropathy (length or non-length dependent neuropathy);<\/li>\n<li>Abnormal warm and\/or cooling threshold at the foot assessed by quantitative sensory testing (QST);<\/li>\n<li>Reduced intraepidermal nerve fibres (IENF) density at the distal leg.<\/li>\n<\/ol>\n<p>SFN are ruled out in the presence of:<\/p>\n<ol>\n<li>any sign of large fibre impairment (light touch and\/or vibratory and\/or proprioceptive sensory loss and\/or absent deep tendon reflexes);<\/li>\n<li>any sign of motor fibre impairment (muscle waste and\/or weakness);<\/li>\n<li>any abnormality on sensorimotor nerve conduction study (NCS).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Reference:<\/strong><\/p>\n<ol>\n<li>Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, Broglio L, Granieri E, Lauria G. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain. 2008 Jul;131(Pt 7):1912-25. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18524793\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Sep 15, 2009<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[2],"tags":[16,15,14,13,1394,1393,1300,1392,1391,1390,1389,1395],"class_list":["post-2468","post","type-post","status-publish","format-standard","hentry","category-neurology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-fibra","tag-fibre","tag-neurology","tag-neuropathy","tag-neuropatia","tag-pequena","tag-sfn","tag-small"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2468"}],"version-history":[{"count":2,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2468\/revisions"}],"predecessor-version":[{"id":8981,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2468\/revisions\/8981"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}