{"id":2470,"date":"2009-09-02T15:35:38","date_gmt":"2009-09-02T15:35:38","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/oncop\/"},"modified":"2025-05-14T19:09:01","modified_gmt":"2025-05-14T19:09:01","slug":"oncop","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/oncop\/","title":{"rendered":"Dose Equivalence Table for Opioid Analgesics"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Equianalgesic tables aid the clinician in making these conversions by providing a rough estimate for starting doses of the new opioid that may produce approximately the same amount of analgesia. Morphine (10 mg IM) is the gold standard to which all other opioids are compared.<\/p>\n<p><!--more--><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td rowspan=\"2\"><strong>Drug<br \/>\n<\/strong><\/td>\n<td colspan=\"2\" align=\"center\"><strong> Equivalent dose (mg)<br \/>\n(compared to morphine 10 mg IM)<br \/>\n<\/strong><\/td>\n<td rowspan=\"2\" align=\"center\"><strong>Duration of action (Hours)<br \/>\n<\/strong><\/td>\n<\/tr>\n<tr>\n<td align=\"center\"><strong>Parenteral<br \/>\n<\/strong><\/td>\n<td align=\"center\"><strong> Oral<br \/>\n<\/strong><\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\"><strong> Strong Opioids Agonists<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Morphine<\/td>\n<td align=\"center\">10<\/td>\n<td align=\"center\">60<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<tr>\n<td>Oxycodone<\/td>\n<td align=\"center\">15<\/td>\n<td align=\"center\">30<\/td>\n<td align=\"center\">2-4<\/td>\n<\/tr>\n<tr>\n<td>Hydromorphone<\/td>\n<td align=\"center\">1.5<\/td>\n<td align=\"center\">7.5<\/td>\n<td align=\"center\">2-4<\/td>\n<\/tr>\n<tr>\n<td>Anileridine<\/td>\n<td align=\"center\">25<\/td>\n<td align=\"center\">75<\/td>\n<td align=\"center\">2-3<\/td>\n<\/tr>\n<tr>\n<td>Levorphanol<\/td>\n<td align=\"center\">2<\/td>\n<td align=\"center\">4<\/td>\n<td align=\"center\">4-8<\/td>\n<\/tr>\n<tr>\n<td>Meperidine<\/td>\n<td align=\"center\">75<\/td>\n<td align=\"center\">300<\/td>\n<td align=\"center\">1-3<\/td>\n<\/tr>\n<tr>\n<td>Oxymorphone<\/td>\n<td align=\"center\">1.5<\/td>\n<td align=\"center\">5 (rectal)<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<tr>\n<td>Methadone<\/td>\n<td align=\"center\">&#8211;<\/td>\n<td align=\"center\">&#8211;<\/td>\n<td align=\"center\">&#8211;<\/td>\n<\/tr>\n<tr>\n<td>Heroin<\/td>\n<td align=\"center\">5-8<\/td>\n<td align=\"center\">10-15<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\"><strong> Weak Opioids Agonists<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Codeine<\/td>\n<td align=\"center\">120<\/td>\n<td align=\"center\">200<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<tr>\n<td>Propoxyphene<\/td>\n<td align=\"center\">50<\/td>\n<td align=\"center\">100<\/td>\n<td align=\"center\">2-4<\/td>\n<\/tr>\n<tr>\n<td colspan=\"4\"><strong> Mixed Agonists-Antagonists<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Pentazocine<\/td>\n<td align=\"center\">60<\/td>\n<td align=\"center\">180<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<tr>\n<td>Nalbuphine<\/td>\n<td align=\"center\">10<\/td>\n<td align=\"center\">&#8211;<\/td>\n<td align=\"center\">3-6<\/td>\n<\/tr>\n<tr>\n<td>Butorphanol<\/td>\n<td align=\"center\">2<\/td>\n<td align=\"center\">&#8211;<\/td>\n<td align=\"center\">3-4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Total daily oral morphine equivalent conversion table.<\/strong><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td><strong> Drug<\/strong><\/td>\n<td align=\"center\"><strong> Dose \u00d7 conversion factor<br \/>\n<\/strong><\/td>\n<\/tr>\n<tr>\n<td>Pethidine (oral)<\/td>\n<td align=\"center\">\u00d70.125<\/td>\n<\/tr>\n<tr>\n<td>Pethidine (i.v.)<\/td>\n<td align=\"center\">\u00d70.4<\/td>\n<\/tr>\n<tr>\n<td>Methadone<\/td>\n<td align=\"center\">\u00d71.5<\/td>\n<\/tr>\n<tr>\n<td>Oxycodone<\/td>\n<td align=\"center\">\u00d71.5<\/td>\n<\/tr>\n<tr>\n<td>Buprenorphine<\/td>\n<td align=\"center\">\u00d750<\/td>\n<\/tr>\n<tr>\n<td>Tramadol<\/td>\n<td align=\"center\">x0.20<\/td>\n<\/tr>\n<tr>\n<td>Codeine<\/td>\n<td align=\"center\">\u00d70.16<\/td>\n<\/tr>\n<tr>\n<td>Dextropropoxyphene<\/td>\n<td align=\"center\">\u00d70.1<\/td>\n<\/tr>\n<tr>\n<td>Morphine (i.v.)<\/td>\n<td align=\"center\">\u00d73<\/td>\n<\/tr>\n<tr>\n<td>Morphine (oral)<\/td>\n<td align=\"center\">\u00d71<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>References:<\/strong><\/p>\n<p><!-- [if gte mso 9]><xml> <w:WordDocument> <w:View>Normal<\/w:View> <w:Zoom>0<\/w:Zoom> <w:HyphenationZone>21<\/w:HyphenationZone> <w:Compatibility> <w:BreakWrappedTables \/> <w:SnapToGridInCell \/> <w:WrapTextWithPunct \/> <w:UseAsianBreakRules \/> <\/w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4<\/w:BrowserLevel> <\/w:WordDocument> <\/xml><![endif]--> <!-- \/* Style Definitions *\/ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:\"\"; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:\"Times New Roman\"; mso-fareast-font-family:\"Times New Roman\";} span.citation-abbreviation {mso-style-name:citation-abbreviation;} span.citation-publication-date {mso-style-name:citation-publication-date;} span.citation-volume {mso-style-name:citation-volume;} span.citation-issue {mso-style-name:citation-issue;} span.citation-flpages {mso-style-name:citation-flpages;} @page Section1 {size:612.0pt 792.0pt; margin:70.85pt 3.0cm 70.85pt 3.0cm; mso-header-margin:36.0pt; mso-footer-margin:36.0pt; mso-paper-source:0;} div.Section1 {page:Section1;} --> <!-- [if gte mso 10]> <mce:style><! \/* Style Definitions *\/ table.MsoNormalTable {mso-style-name:\"Tabla normal\"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:\"\"; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:\"Times New Roman\";} --> <!--[endif] --><\/p>\n<ol>\n<li>Nissen LM, Tett SE, Cramond T, Williams B, Smith MT. Opioid analgesic prescribing and use &#8211; an audit of analgesic prescribing by general practitioners and The Multidisciplinary Pain Centre at Royal Brisbane Hospital. Br J Clin Pharmacol. 2001 Dec;52(6):693-8.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11736881\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>Argoff CE, Silvershein DI. A comparison of long- and short-acting opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs. Mayo Clin Proc. 2009 Jul;84(7):602-12.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19567714\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Sep 03, 2009<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[272],"tags":[439,1410,1409,1408,1407,1406,1405,1404,436,1411],"class_list":["post-2470","post","type-post","status-publish","format-standard","hentry","category-oncology","tag-analgesicos","tag-analgesics","tag-dose","tag-dosis","tag-equivalence","tag-equivalencia","tag-oncology","tag-opioid","tag-opioides","tag-table"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2470"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2470\/revisions"}],"predecessor-version":[{"id":9417,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2470\/revisions\/9417"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}