{"id":2511,"date":"2009-03-08T12:10:41","date_gmt":"2009-03-08T12:10:41","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/neurotsc\/"},"modified":"2025-05-14T19:10:25","modified_gmt":"2025-05-14T19:10:25","slug":"neurotsc","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/neurotsc\/","title":{"rendered":"Diagnostic Criteria for Tuberous Sclerosis Complex (TSC)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<div class=\"Section1\">\n<p class=\"MsoNormal\">The diagnostic criteria for tuberous sclerosis complex (TSC) were revised at the Tuberous Sclerosis Complex Consensus Conference, July 1998.<\/p>\n<p class=\"MsoNormal\"><strong>Definite TSC:<\/strong> Two major features or one major feature plus two minor features<\/p>\n<p class=\"MsoNormal\"><strong>Probable TSC:<\/strong> One major feature plus one minor feature<\/p>\n<p class=\"MsoNormal\"><strong>Possible TSC:<\/strong> One major feature or two or more minor features<\/p>\n<p><!--more--><\/p>\n<p class=\"MsoNormal\"><strong>Major Features <\/strong><\/p>\n<ul style=\"margin-top: 0cm;\">\n<li class=\"MsoNormal\">Facial angiofibromas or forehead plaque<\/li>\n<li class=\"MsoNormal\">Nontraumatic ungual or periungual fibromas<\/li>\n<li class=\"MsoNormal\">Hypomelanotic macules (three or more)<\/li>\n<li class=\"MsoNormal\">Shagreen patch (connective tissue nevus)<\/li>\n<li class=\"MsoNormal\">Multiple retinal nodular hamartomas<\/li>\n<li class=\"MsoNormal\">Cortical tuber 1<\/li>\n<li class=\"MsoNormal\">Subependymal nodule<\/li>\n<li class=\"MsoNormal\">Subependymal giant cell astrocytoma<\/li>\n<li class=\"MsoNormal\">Cardiac rhabdomyoma, single or multiple<\/li>\n<li class=\"MsoNormal\">Lymphangiomyomatosis 2<\/li>\n<li class=\"MsoNormal\">Renal angiomyolipoma 2<\/li>\n<\/ul>\n<p class=\"MsoNormal\"><strong>Minor Features <\/strong><\/p>\n<ul style=\"margin-top: 0cm;\">\n<li class=\"MsoNormal\">Multiple randomly-distributed pits in dental enamel<\/li>\n<li class=\"MsoNormal\">Hamartomatous rectal polyps<\/li>\n<li class=\"MsoNormal\">Bone cysts<\/li>\n<li class=\"MsoNormal\">Cerebral white matter radial migration lines 1,3<\/li>\n<li class=\"MsoNormal\">Gingival fibromas<\/li>\n<li class=\"MsoNormal\">Nonrenal hamartoma<\/li>\n<li class=\"MsoNormal\">Retinal achromic patch<\/li>\n<li class=\"MsoNormal\">&#8220;Confetti&#8221; skin lesions<\/li>\n<li class=\"MsoNormal\">Multiple renal cysts<\/li>\n<\/ul>\n<p class=\"MsoNormal\">1. Cerebral cortical dysplasia and cerebral white matter migration tracts occurring together are counted as one rather than two features of TSC.<br \/>\n2. When both lymphangiomyomatosis and renal angiomyolipomas are present, other features of tuberous sclerosis must be present before TSC is diagnosed.<br \/>\n3. White matter migration lines and focal cortical dysplasia are often seen in individuals with TSC; however, because these lesions can be seen independently and are relatively nonspecific, they are considered a minor diagnostic criteria for TSC.<\/p>\n<\/div>\n<div class=\"Section1\"><\/div>\n<div><\/div>\n<div class=\"Section1\">\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<\/div>\n<ol>\n<li>Roach ES, DiMario FJ, Kandt RS, Northrup H. Tuberous Sclerosis Consensus Conference: recommendations for diagnostic evaluation. National Tuberous Sclerosis Association. J Child Neurol. 1999 Jun;14(6):401-7.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10385849\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Crino PB, Nathanson KL, Henske EP. The tuberous sclerosis complex. N Engl J Med. 2006 Sep 28;355(13):1345-56.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17005952\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: July 05, 2005<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[2],"tags":[95,16,15,14,13,94,1300,93,92,91,90],"class_list":["post-2511","post","type-post","status-publish","format-standard","hentry","category-neurology","tag-complex","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-esclerosis","tag-neurology","tag-sclerosis","tag-tsc","tag-tuberosa","tag-tuberous"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2511"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2511\/revisions"}],"predecessor-version":[{"id":9143,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2511\/revisions\/9143"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}