{"id":2526,"date":"2009-03-05T18:21:43","date_gmt":"2009-03-05T18:21:43","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/hempv\/"},"modified":"2025-05-14T19:10:53","modified_gmt":"2025-05-14T19:10:53","slug":"hempv","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/hempv\/","title":{"rendered":"Diagnostic Criteria for Polycythemia Vera (PV)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<div class=\"Section1\">\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>Criteria PVSG (Polycythemia Vera Study Group) <\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 Raised red cell mass (RCM), male <span style=\"text-decoration: underline;\">&gt;<\/span> 36 ml\/kg, female <span style=\"text-decoration: underline;\">&gt;<\/span> 32 ml\/kg<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A2 Normal arterial oxygen saturation <span style=\"text-decoration: underline;\">&gt;<\/span> 92%<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A3 Splenomegaly<\/p>\n<p><!--more--><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B1 Platelet count &gt; 400 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B2 White blood cell count (WBC) &gt; 12 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B3 Leucocyte alkaline phosphatase &gt; 100<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B4 Serum B12 &gt; 900 pg\/ml or unbound B12 binding capacity &gt; 220 pg\/ml<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong><br \/>\nDiagnosis<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 + A3 establishes PV<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 + two of category B establishes PV<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong><br \/>\nCriteria BCSH (British Committee for Standards in Haematology) <\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 Raised RCM or hematocrit (HCT) <span style=\"text-decoration: underline;\">&gt;<\/span> 0.60 (males), <span style=\"text-decoration: underline;\">&gt;<\/span> 0.56 (females)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A2 No secondary erythrocytosis<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A3 Palpable spleen<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A4 Abnormal karyotype<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B1 Platelet count &gt; 400 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B2 Neutrophil count &gt; 10 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B3 Splenomegaly on ultrasound scanning<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B4 Low serum EPO or characteristic burst forming units &#8211; erythroid (BFU-E) growth<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong><br \/>\nDiagnosis<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 + A3 or A4 establishes PV<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 + two of B establishes PV<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong><br \/>\nCriteria WHO (World Health Organization) <\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 Raised RCM or haemoglobin (Hb) &gt; 18.5 (males), &gt; 16.5 (females)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A2 No secondary erythrocytosis<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A3 Splenomegaly<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A4 Abnormal karyotype (other than Ph chromosome or BCR\/ABL fusion gene in marrow cells)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A5 Endogenous erythroid colony (EEC) formation<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B1 Platelet count &gt; 400 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B2 WBC &gt; 12 x 109\/l<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B3 Bone marrow biopsy (BMB) showing panmyelosis with erythroid and megakaryocytic proliferation<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">B4 Low serum erythropoietin (EPO)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong><br \/>\nDiagnosis<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 and any other category A establishes PV<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">A1 + A2 + two of category B establishes PV<\/p>\n<p class=\"MsoNormal\">\n<\/div>\n<div class=\"Section1\"><\/div>\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<ol>\n<li>Turkington RC, Arnold EC, Percy MJ, Ranaghan LA, Cuthbert RJ, McMullin MF. Comparison of diagnostic criteria for polycythaemia vera. Hematology. 2007 Apr;12(2):123-30.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17454193\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007 Aug 15;110(4):1092-7.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17488875\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Pearson TC, Messinezy M. The diagnostic criteria of polycythaemia rubra vera. Leuk Lymphoma. 1996 Sep;22 Suppl 1:87-93.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8951778\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Berlin NI. Diagnosis and classification of the polycythemias.\u00a0Semin Hematol 1975;12(4):339\u2013351.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Sep 10, 2007<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[16,15,14,13,1381,1610,1609,1608,1611],"class_list":["post-2526","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-hematology","tag-policitemia","tag-polycythemia","tag-pv","tag-vera"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2526"}],"version-history":[{"count":3,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2526\/revisions"}],"predecessor-version":[{"id":8829,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2526\/revisions\/8829"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2526"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2526"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}