{"id":2542,"date":"2009-03-03T14:46:05","date_gmt":"2009-03-03T14:46:05","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/ginpcos\/"},"modified":"2025-05-14T19:11:21","modified_gmt":"2025-05-14T19:11:21","slug":"ginpcos","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/ginpcos\/","title":{"rendered":"Diagnostic Criteria in Polycystic Ovary Syndrome (PCOS)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder of reproductive-aged women.\u00a0This syndrome is predominantly characterized by irregular menstrual cycles, hyperandrogenism, and characteristic findings on pelvic ultrasound. Women with PCOS also frequently suffer from metabolic dysfunction, obesity, infertility and are at an increased risk of pregnancy complications and long-term cardiovascular disease.<!--more--><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>Revised diagnostic criteria of PCOS<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">1999 criteria (both 1 and 2)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">1. Chronic <span class=\"SpellE\">anovulation<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">2. Clinical and\/or biochemical signs of <span class=\"SpellE\">hyperandrogenism<\/span>, and exclusion of other <span class=\"SpellE\">aetiologies<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Revised 2003 criteria (2 out of 3)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">1. <span class=\"SpellE\">Oligo<\/span>&#8211; and\/or <span class=\"SpellE\">anovulation<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">2. Clinical and\/or biochemical signs of <span class=\"SpellE\">hyperandrogenism<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">3. Polycystic ovaries<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><span class=\"GramE\">and<\/span> exclusion of other <span class=\"SpellE\">aetiologies<\/span> (congenital adrenal <span class=\"SpellE\">hyperplasias<\/span>, androgen-secreting <span class=\"SpellE\">tumours<\/span>, Cushing\u2019s syndrome)<\/p>\n<p style=\"margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-weight: normal;\">Other Proposed Diagnostic Criteria in Polycystic Ovary Syndrome<\/span><\/p>\n<ol>\n<li>Inappropriate <span class=\"SpellE\">gonadotropin<\/span> secretion<br \/>\n<span style=\"text-indent: -18pt;\">a) <\/span><span style=\"text-indent: -18pt;\"> Elevated LH-to-FSH ratio<br \/>\n<span style=\"text-indent: -18pt;\">b) <\/span><span style=\"text-indent: -18pt;\"> Abnormal response to GnRH agonist testing<\/span><br \/>\n<\/span><\/li>\n<\/ol>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> 2. <!--[endif]--> Hyperandrogenism<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> a) <!--[endif]--> Hirsutism, androgenic alopecia, acne<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> b) <!--[endif]--> <span class=\"SpellE\">Hyperandrogenemia<br \/>\nI. Total testosterone<br \/>\nII. Free testosterone (free androgen index, etc.)<em style=\"font-family: helvetica, arial, sans-serif;\"><br \/>\n<\/em><\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> 3. <!--[endif]--> Ovarian appearance<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> a) <!--[endif]--> Polycystic-appearing ovaries<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> b) <!--[endif]--> Increased (stromal) size<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><!-- [if !supportLists]--> 4. <!--[endif]--> <span style=\"font-family: georgia, palatino, serif;\">Insulin resistance<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> a) <!--[endif]--> Acanthosis nigricans<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> b) <!--[endif]--> Fasting measures of insulin\/glucose<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> c) <!--[endif]--> Oral glucose tolerance test<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> d) <!--[endif]--> Dynamic tests of insulin sensitivity<\/span><br \/>\n<span style=\"font-family: georgia, palatino, serif;\">I. Euglycemic clamp<br \/>\nII. Frequently sampled intravenous glucose tolerance test<em><br \/>\n<\/em><\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 36pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> 5. <!--[endif]--> Chronic anovulation<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> a) <!--[endif]--> Self-reported history<\/span><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 72pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\"><span style=\"font-family: georgia, palatino, serif;\"><!-- [if !supportLists]--> b) <!--[endif]--> Tests of ovulatory function<\/span><br \/>\n<span style=\"font-family: georgia, palatino, serif;\">I. Basal body temperature charting<br \/>\nII. Urinary LH testing<br \/>\nIII. Serum progesterone measurement<br \/>\nIV. Endometrial biopsy<\/span><em><span style=\"font-family: helvetica, arial, sans-serif;\"><br \/>\n<\/span><\/em><\/p>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><span class=\"GramE\">FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasing hormone; LH, luteinizing hormone.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<ol style=\"margin-top: 0cm;\">\n<li>The Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum\u00a0Reprod. 2004 Jan;19(1):41-7.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14688154\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Legro\u00a0R. Diagnostic Criteria in Polycystic Ovary Syndrome.\u00a0Semin\u00a0Reprod\u00a0Med. 2003 Aug;21(3):267-75\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14593549\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<li>Reaven\u00a0G. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals.\u00a0Endocrinol\u00a0Metab\u00a0Clin\u00a0North Am. 2004 Jun;33(2):283-303.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15158520\/\" target=\"_blank\" rel=\"noopener\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: May 10, 2005<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[87],"tags":[16,15,14,13,1322,1484,498,1659,1658,1654,1653,5,4],"class_list":["post-2542","post","type-post","status-publish","format-standard","hentry","category-obstetrics-gynecology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-endocrinology","tag-gynecology","tag-ovario","tag-ovary","tag-pcos","tag-poliquistico","tag-polycystic","tag-sindrome","tag-syndrome"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2542"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2542\/revisions"}],"predecessor-version":[{"id":10190,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2542\/revisions\/10190"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}