{"id":2555,"date":"2009-03-02T01:11:33","date_gmt":"2009-03-02T01:11:33","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/reumctd\/"},"modified":"2025-05-14T19:11:29","modified_gmt":"2025-05-14T19:11:29","slug":"reumctd","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/reumctd\/","title":{"rendered":"Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Mixed connective tissue disease (MCTD) has signs and symptoms of a combination of disorders, primarily lupus, scleroderma, and polymyositis. Many people with this uncommon disease also have Sjogren&#8217;s syndrome. For this reason, MCTD is sometimes called an overlap disease.<br \/>\n<!--more--><br \/>\n<strong>Alarcon-Segovia Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">1. Serological criteria: Positive anti U1 RNP at haemagglutination titer &gt;1:1600<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">2. Clinical criteria:<\/p>\n<ul>\n<li>Oedema of hands<\/li>\n<li>Synovitis<\/li>\n<li>Myositis<\/li>\n<li>Reynaud&#8217;s<\/li>\n<li>Acrosclerosis<\/li>\n<\/ul>\n<p class=\"MsoNormal\">Requirements:<\/p>\n<ol>\n<li class=\"MsoNormal\">Serological<\/li>\n<li class=\"MsoNormal\">At least 3 clinical features<\/li>\n<li class=\"MsoNormal\">Association of hand oedema, Reynaud&#8217;s and acrosclerosis requires at least one other feature<\/li>\n<\/ol>\n<p class=\"MsoNormal\"><strong>Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)<\/strong><\/p>\n<p class=\"MsoNormal\">Common Symptoms<\/p>\n<ol>\n<li class=\"MsoNormal\">Reynaud&#8217;s Phenomenon<\/li>\n<li class=\"MsoNormal\">Swollen fingers or hands<\/li>\n<\/ol>\n<p class=\"MsoNormal\">Presence of Anti U1 RNP<\/p>\n<p class=\"MsoNormal\">Mixed findings<\/p>\n<p class=\"MsoNormal\">A. Systemic lupus erythematosus (SLE) like<\/p>\n<ul>\n<li class=\"MsoNormal\">Polyarthritis<\/li>\n<li class=\"MsoNormal\">Pericarditis\/pleuritis<\/li>\n<li class=\"MsoNormal\">Lymphadenopathy<\/li>\n<li class=\"MsoNormal\">Facial erithema<\/li>\n<li class=\"MsoNormal\">Leucopenia\/thrombocytopenia<\/li>\n<\/ul>\n<p class=\"MsoNormal\">B. Scleroderma like<\/p>\n<ul>\n<li class=\"MsoNormal\">Sclerodactyly<\/li>\n<li class=\"MsoNormal\">Pulmonary fibrosis<\/li>\n<li class=\"MsoNormal\">Esophageal dysmotility<\/li>\n<\/ul>\n<p class=\"MsoNormal\">C. Polymyositis like<\/p>\n<ul>\n<li class=\"MsoNormal\">Muscle weakness<\/li>\n<li class=\"MsoNormal\">High creatine phosphokinase (CPK)<\/li>\n<li class=\"MsoNormal\">Myophatic electromyogram (EMG)<\/li>\n<\/ul>\n<p class=\"MsoNormal\">Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.<\/p>\n<div class=\"Section1\">\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<\/div>\n<ol>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\" align=\"left\">Alarcon-Segovia D, Cardiel MH. Comparison between 3 diagnostic criteria for mixed connective tissue disease. Study of 593 patients. J Rheumatol. 1989 Mar;16(3):328-34. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2724251\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\" align=\"left\">Alarcon-Segovia D. Mixed connective tissue disease and overlap syndromes. Clin Dermatol. 1994 Apr-Jun;12(2):309-16. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8076270\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\" align=\"left\">Tiddens HA, van der Net JJ, de Graeff-Meeder ER, Fiselier TJ, de Rooij DJ, van Luijk WH, Herzberger R, van Suijlekom LW, van Venrooij WJ, Zegers BJ, et al. Juvenile-onset mixed connective tissue disease: longitudinal follow-up. J Pediatr. 1993 Feb;122(2):191-7. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/8429431\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\" align=\"left\">Haroon N, Nisha RS, Chandran V, Bharadwaj A. Pulmonary hypertension not a major feature of early mixed connective tissue disease: A prospective clinicoserological study. J Postgrad Med. 2005 Apr-Jun;51(2):104-8. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16006700\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Mar 24, 2006<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[45],"tags":[1702,1701,16,15,14,51,1700,50,1699,1698,759,1070,1697,1703],"class_list":["post-2555","post","type-post","status-publish","format-standard","hentry","category-rheumatology","tag-conectivo","tag-connective","tag-criteria","tag-criterios","tag-diagnostic","tag-disease","tag-emtc","tag-enfermedad","tag-mctd","tag-mixed","tag-mixta","tag-rheumatology","tag-tejido","tag-tissue"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2555"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2555\/revisions"}],"predecessor-version":[{"id":9456,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2555\/revisions\/9456"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}