{"id":2560,"date":"2009-02-28T23:32:33","date_gmt":"2009-02-28T23:32:33","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/hemmastcla\/"},"modified":"2025-05-14T19:11:32","modified_gmt":"2025-05-14T19:11:32","slug":"hemmastcla","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/hemmastcla\/","title":{"rendered":"Diagnostic Criteria for Systemic Mastocytosis (SM)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<div class=\"Section1\">\n<p class=\"MsoNormal\">If at least 1 major and 1 one minor, or at least 3 minor criteria, are met, the diagnosis of Systemic Mastocytosis (SM) can be established.<\/p>\n<p><!--more--><\/p>\n<p class=\"MsoNormal\"><strong>Major Criteria:<\/strong> Multifocal dense infiltrates of mast cells in bone marrow or other extracutaneous organ(s) (&gt;15 mast cells in aggregate)<\/p>\n<p class=\"MsoNormal\"><strong>Minor <\/strong><strong>Criteria:<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 35.85pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\">a) Mast cells in bone marrow or other extracutaneous organ(s) show an abnormal morphology (&gt; 25%)<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 35.85pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\">b) C-kit mutation at codon 816 in extracutaneous organ(s). (Activating mutations at codon 816; in most cases, c-kit D816V)<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 35.85pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\">c) Mast cells in bone marrow express CD2 and\/or CD25<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 35.85pt; text-indent: -18pt; margin-top: 0pt; margin-bottom: 0pt;\">d) Serum total tryptase &gt; 20 ng\/mL (does not count in patients who have associated hematologic clonal non-mast cell lineage disease-type disease)<\/p>\n<\/div>\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<ol style=\"margin-top: 0cm;\">\n<li>Akin C, Metcalfe DD. Systemic mastocytosis. Annu Rev Med. 2004;55:419-32.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/14746529\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<li>O&#8217;Brien S, Tefferi A, Valent P. Chronic myelogenous leukemia and myeloproliferative disease. Hematology (Am Soc Hematol Educ Program). 2004;146-62. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15561681\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<\/div>\n<div class=\"Section1\"><\/div>\n<div class=\"Section1\"><\/div>\n<div class=\"Section1\">Created: June 21, 2005<\/div>\n<div class=\"Section1\"><\/div>\n<\/div>\n<\/div>\n<p><\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[16,15,14,13,1381,1716,1715,1714,1088],"class_list":["post-2560","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-hematology","tag-mastocitosis","tag-mastocytosis","tag-sm","tag-systemic"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2560"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2560\/revisions"}],"predecessor-version":[{"id":9375,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2560\/revisions\/9375"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}