{"id":2566,"date":"2009-02-28T20:18:02","date_gmt":"2009-02-28T20:18:02","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/gasfhf\/"},"modified":"2025-05-14T19:11:52","modified_gmt":"2025-05-14T19:11:52","slug":"gasfhf","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/gasfhf\/","title":{"rendered":"King\u00b4s College Hospital Criteria for Liver Transplantation in Fulminant Hepatic Failure"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>In acetaminophen-induced fulminant hepatic failure, survival correlated with arterial blood pH, peak prothrombin time, and serum creatinine&#8211;a pH less than 7.30, prothrombin time greater than 100 s, and creatinine greater than 300 mumol\/L indicating a poor prognosis.<!--more--><\/p>\n<p class=\"MsoNormal\"><strong>Acetaminophen-induced disease<\/strong><\/p>\n<p class=\"MsoNormal\">Arterial pH &lt;7.3 (irrespective of the grade of encephalopathy)<\/p>\n<p class=\"MsoNormal\"><strong>or<\/strong><\/p>\n<ul>\n<li class=\"MsoNormal\">Grade III or IV encephalopathy, <strong>and<\/strong><\/li>\n<li class=\"MsoNormal\">Prothrombin time &gt;100 seconds, <strong>and<\/strong><\/li>\n<li class=\"MsoNormal\">Serum creatinine &gt;3.4mg\/dl (301 \u00b5mol\/L)<\/li>\n<\/ul>\n<p class=\"MsoNormal\"><strong>All other causes of fulminant hepatic failure<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Prothrombin time &gt;100 seconds (irrespective of the grade of encephalopathy)<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>or<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Any three of the following variables (irrespective of the grade of encephalopathy)<\/p>\n<ol>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Age &lt;10 years or &gt;40 years<\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Etiology: non-A, non-B hepatitis, halothane hepatitis, idiosyncratic drug reactions<\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Duration of jaundice before onset of encephalopathy &gt;7 days<\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Prothrombin time &gt;50 seconds<\/p>\n<\/li>\n<li>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Serum bilirrubin &gt;18 mg\/dl (308 \u00b5mol\/L)<\/p>\n<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<ol>\n<li>O&#8217;Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 1989 Aug;97(2):439-45.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2490426\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Created: Jan 29, 2008<\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[53],"tags":[1011,16,15,674,901,1729,1728,1413,648,529,1725,1427,1727,524,1724,1726],"class_list":["post-2566","post","type-post","status-publish","format-standard","hentry","category-gastroenterology","tag-college","tag-criteria","tag-criterios","tag-failure","tag-fallo","tag-fulminant","tag-fulminante","tag-gastroenterology","tag-hepatic","tag-hepatico","tag-higado","tag-hospital","tag-king","tag-liver","tag-transplantation","tag-transplante"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=2566"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2566\/revisions"}],"predecessor-version":[{"id":8947,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/2566\/revisions\/8947"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=2566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=2566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=2566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}