{"id":41,"date":"2009-02-24T18:55:56","date_gmt":"2009-02-24T18:55:56","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/hemdic\/"},"modified":"2025-05-14T21:02:36","modified_gmt":"2025-05-14T21:02:36","slug":"hemdic","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/hemdic\/","title":{"rendered":"Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Disseminated intravascular coagulation is a condition in which small blood clots develop throughout the bloodstream, blocking small blood vessels. The increased clotting depletes the platelets and clotting factors needed to control bleeding, causing excessive bleeding.<\/p>\n<p><!--more--><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 22.2222%;\"><strong>Classification<\/strong><\/td>\n<td style=\"width: 31.8681%;\"><strong>Definition<\/strong><\/td>\n<td style=\"width: 45.9096%;\"><strong>Diagnostic criteria<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 22.2222%;\">Biological DIC<\/td>\n<td style=\"width: 31.8681%;\">Hemostatic defect without clinical manifestations<\/td>\n<td style=\"width: 45.9096%;\">\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Elevated D-Dimers<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>and<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">1 major criterion for consumption of platelets or coagulation factors<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>or<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">2 minor criteria for consumption of platelets or coagulation factors<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 22.2222%;\">Clinical DIC<\/td>\n<td style=\"width: 31.8681%;\">Hemostatic defect with hemorrhagic or ischemic manifestations<\/td>\n<td style=\"width: 45.9096%;\">Same as above + microvascular bleeding and\/or thrombosis<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 22.2222%;\">Complicated DIC<\/td>\n<td style=\"width: 31.8681%;\">Hemostatic defect with hemorrhagic or ischemic manifestations that jeopardize organ function or patient prognosis<\/td>\n<td style=\"width: 45.9096%;\">Same as above + organ failure (single or multiple)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\"><strong>Details of laboratory criteria<\/strong><\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">D-Dimers greater than 500 \u00b5g\u00b7L\u20131<\/p>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Platelet consumption<\/p>\n<ul style=\"margin-top: 0cm;\">\n<li class=\"MsoNormal\">\n<p style=\"margin-top: 0pt; margin-bottom: 0pt;\">Minor: platelet count between 50 and 100,000\u00b7\/mm<sup>3<\/sup><\/p>\n<\/li>\n<li class=\"MsoNormal\">\n<p style=\"margin-top: 0pt; margin-bottom: 0pt;\">Major: platelet count less than 50,000\u00b7\/mm<sup>3<\/sup><\/p>\n<\/li>\n<\/ul>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">Consumption of coagulation factors<\/p>\n<ul style=\"margin-top: 0cm;\">\n<li class=\"MsoNormal\">\n<p style=\"margin-top: 0pt; margin-bottom: 0pt;\">Minor: INR of the PT between 1.2 and 1.5<\/p>\n<\/li>\n<li class=\"MsoNormal\">\n<p style=\"margin-top: 0pt; margin-bottom: 0pt;\">Major: INR of the PT greater than 1.5<\/p>\n<\/li>\n<\/ul>\n<p class=\"MsoNormal\" style=\"margin-top: 0pt; margin-bottom: 0pt;\">INR of the PT = international normalized ratio of the prothrombin time. The elevation of D-Dimers is not specific to DIC. Similarly, the clinical manifestations of DIC are not specific.<\/p>\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References;<\/strong><\/p>\n<ol style=\"margin-top: 0cm;\">\n<li class=\"MsoNormal\">Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86(5):1327-30. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11816725\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/li>\n<\/ol>\n<\/div>\n<div><\/div>\n<div class=\"Section1\">Created: Aug 04, 2005<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[171],"tags":[1348,1870,942,941,16,15,14,13,947,946,945,1381,944],"class_list":["post-41","post","type-post","status-publish","format-standard","hentry","category-hematology","tag-cardiology","tag-cid","tag-coagulacion","tag-coagulation","tag-criteria","tag-criterios","tag-diagnostic","tag-diagnostico","tag-dic","tag-diseminada","tag-disseminated","tag-hematology","tag-intravascular"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/41","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=41"}],"version-history":[{"count":2,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/41\/revisions"}],"predecessor-version":[{"id":8997,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/41\/revisions\/8997"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=41"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=41"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}