{"id":54,"date":"2009-02-26T11:55:27","date_gmt":"2009-02-26T11:55:27","guid":{"rendered":"https:\/\/medicalcriteria.com\/web\/peddigeorge\/"},"modified":"2025-05-14T21:01:08","modified_gmt":"2025-05-14T21:01:08","slug":"peddigeorge","status":"publish","type":"post","link":"https:\/\/medicalcriteria.com\/web\/peddigeorge\/","title":{"rendered":"Diagnostic Criteria for DiGeorge Syndrome (DGS)"},"content":{"rendered":"<div class=\"99c380e4b4a7b96c35d7ddf7dcb434e8\" data-index=\"1\" style=\"float: none; margin:0px 0 0px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<!-- MC 2019- Horizontal -->\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block\"\r\n     data-ad-client=\"ca-pub-0127150553352455\"\r\n     data-ad-slot=\"3806776041\"\r\n     data-ad-format=\"auto\"\r\n     data-full-width-responsive=\"true\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p><\/p>\n<p class=\"MsoNormal\"><strong>Definitive diagnosis<\/strong><\/p>\n<p class=\"MsoNormal\">Male or female patient with reduced numbers of CD3+ T cells (less than 500\/mm3) and two of the three following characteristics:<\/p>\n<p><!--more--><\/p>\n<ol>\n<li class=\"MsoNormal\">Conotruncal cardiac defect (truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, or aberrant right subclavian).<\/li>\n<li class=\"MsoNormal\">Hypocalcemia of greater than 3 weeks&#8217; duration that requires therapy.<\/li>\n<li class=\"MsoNormal\">Deletion of chromosome 22q11.2.<\/li>\n<\/ol>\n<p class=\"MsoNormal\"><strong> Probable diagnosis<\/strong><\/p>\n<p class=\"MsoNormal\">Male or female patient with reduced numbers of CD3+ T cells (less than 1500\/mm3) and a deletion of chromosome 22q11.2.<\/p>\n<p class=\"MsoNormal\"><strong> Possible diagnosis<\/strong><\/p>\n<p class=\"MsoNormal\">Male or female patient with reduced numbers of CD3+ T cells (less than 1500\/mm3) and at least one of the following:<\/p>\n<ol>\n<li class=\"MsoNormal\">Cardiac defect.<\/li>\n<li class=\"MsoNormal\">Hypocalcemia of greater than 3 weeks&#8217; duration that requires therapy.<\/li>\n<li class=\"MsoNormal\">Dysmorphic facies or palatal abnormalities.<\/li>\n<\/ol>\n<p class=\"MsoNormal\">Patients with a definitive or probable diagnosis are assumed to have a greater than 98 and 85 percent probability, respectively, that in 20 years they will still have the same diagnosis. Patients with a possible diagnosis are those that have some but not all of the characteristic clinical or laboratory findings of a particular disorder.<\/p>\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<div class=\"Section1\">\n<p>&nbsp;<\/p>\n<p class=\"MsoNormal\"><strong>References:<\/strong><\/p>\n<div class=\"Section1\">\n<ol>\n<li>\n<p class=\"MsoNormal\">Conley ME, Notarangelo LD, Etzioni A. Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol. 1999 Dec;93(3):190-7. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/10600329\/\" target=\"_blank\" rel=\"noopener noreferrer\">[Medline]<\/a><\/p>\n<\/li>\n<\/ol>\n<\/div>\n<div><\/div>\n<div class=\"Section1\">Created: Oct 17, 2007<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p><\/p>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Sorry, this entry is only available in Espa\u00f1ol.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"no","_lmt_disable":"no","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[441],"tags":[16,15,1838,14,13,1837,1836,667,5,4],"class_list":["post-54","post","type-post","status-publish","format-standard","hentry","category-pediatrics","tag-criteria","tag-criterios","tag-dgs","tag-diagnostic","tag-diagnostico","tag-digeorge","tag-gen","tag-pediatrics","tag-sindrome","tag-syndrome"],"modified_by":"Guillermo Firman","_links":{"self":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/54","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/comments?post=54"}],"version-history":[{"count":4,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/54\/revisions"}],"predecessor-version":[{"id":9071,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/posts\/54\/revisions\/9071"}],"wp:attachment":[{"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/media?parent=54"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/categories?post=54"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicalcriteria.com\/web\/wp-json\/wp\/v2\/tags?post=54"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}